{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:41:13Z","timestamp":1761986473184},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,6,16]],"date-time":"2013-06-16T00:00:00Z","timestamp":1371340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammatory processes during pregnancy might affect fetal lung development and immune responses. We examined the associations of maternal and cord blood <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein levels with respiratory symptoms and eczema in preschool children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was embedded in a population\u2010based prospective cohort study of 4984 children. Generalized estimating equations were used to assess the effect of <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein levels on respiratory symptoms or eczema. C\u2010reactive protein levels were measured during early pregnancy and at birth. Wheezing, lower respiratory tract infections, and eczema until the age of 4\u00a0yr were annually obtained by questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein was not associated with the risks of wheezing and lower respiratory tract infections. Compared to children with maternal <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein in the lowest quarter, children in the highest quarter had increased risks of eczema <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.20 (1.03, 1.40). Compared to children with cord blood <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein lower than 0.20\u00a0mg\/l, those with levels higher than 0.20\u00a0mg\/l had increased risks of wheezing, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.21 (1.07, 1.36), and lower respiratory tract infections, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.21 (1.05, 1.39), but not of eczema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that elevated maternal <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein in pregnancy is associated with a higher risk of eczema, and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein in cord blood with a higher risk of wheezing and lower respiratory tract infections in the first 4\u00a0yrs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12094","type":"journal-article","created":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T02:58:20Z","timestamp":1371437900000},"page":"469-475","source":"Crossref","is-referenced-by-count":18,"title":["Influence of maternal and cord blood <scp>C<\/scp>\u2010reactive protein on childhood respiratory symptoms and eczema"],"prefix":"10.1111","volume":"24","author":[{"given":"Agnes M. M.","family":"Sonnenschein\u2010van der Voort","sequence":"first","affiliation":[{"name":"The Generation R Study Group Erasmus Medical Center Rotterdam The Netherlands"},{"name":"Department of Pediatrics Division of Respiratory Medicine Erasmus Medical Center Rotterdam The Netherlands"},{"name":"Department of Epidemiology Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent W. V.","family":"Jaddoe","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus Medical Center Rotterdam The Netherlands"},{"name":"Department of Epidemiology Erasmus Medical Center Rotterdam The Netherlands"},{"name":"Department of Pediatrics Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri\u00ebtte A.","family":"Moll","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Hofman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf J. P.","family":"van der Valk","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus Medical Center Rotterdam The Netherlands"},{"name":"Department of Pediatrics Division of Respiratory Medicine Erasmus Medical Center Rotterdam The Netherlands"},{"name":"Department of Epidemiology Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan C.","family":"de Jongste","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Respiratory Medicine Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liesbeth","family":"Duijts","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Respiratory Medicine Erasmus Medical Center Rotterdam The Netherlands"},{"name":"Department of Epidemiology Erasmus Medical Center Rotterdam The Netherlands"},{"name":"Department of Pediatrics Division of Neonatology Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902113400607"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00040708"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2007.01122.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.023911"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60356-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.03.049"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000187899.34379.b0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2004.07.005"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834c58e5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.08.056"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199708000-00003"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi323"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(02)00085-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200610-1441OC"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14542-4"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-012-9735-1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030483"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00178110"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csda.2007.04.020"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq137"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.02.022"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020026"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.137"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200512-1978OC"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.941203"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181fed334"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh179"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/25.3.609"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.12094","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.12094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T07:14:44Z","timestamp":1696230884000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.12094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,16]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/pai.12094"],"URL":"https:\/\/doi.org\/10.1111\/pai.12094","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,16]]}}}