{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:36:26Z","timestamp":1790786186126,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,6,16]],"date-time":"2013-06-16T00:00:00Z","timestamp":1371340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Atopic dermatitis (\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      ) is associated with multiple comorbid conditions, such as asthma and food allergy. We sought to determine the impact of eczema severity on the development of these disorders and other non\u2010atopic comorbidities in\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We used the 2007\n                      <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\n                      ational\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      urvey of\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      hildren's\n                      <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\n                      ealth, a prospective questionnaire\u2010based study of a nationally representative sample of 91,642 children aged 0\u201317\u00a0yr. Prevalence and severity of eczema, asthma, hay fever and food allergy, sleep impairment, healthcare utilization, recurrent ear infections, and visual and dental problems were determined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In general, more severe eczema is correlated with poorer overall health, impaired sleep, and increased healthcare utilization, including seeing a specialist, compared with children with mild or moderate disease (Rao\u2010Scott chi\u2010squared test, p\u00a0&lt;\u00a00.0001). Severe eczema was associated with a higher prevalence of comorbid chronic health disorders, including asthma, hay fever, and food allergies (p\u00a0&lt;\u00a00.0001). In addition, the severity of eczema was directly related to the severity of the comorbidities. These associations remained significant in multivariate logistic regression models that included age, sex, and race\/ethnicity. Severe eczema was also associated with recent dental problems, including bleeding gums (p\u00a0&lt;\u00a00.0001), toothache (p\u00a0=\u00a00.0004), but not broken teeth (p\u00a0=\u00a00.04) or tooth decay (p\u00a0=\u00a00.13).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data indicate that severe eczema is associated with multiple comorbid chronic health disorders, impaired overall health, and increased healthcare utilization. Further, these data suggest that children with eczema are at risk of decreased oral health. Future studies are warranted to verify this novel association.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.12095","type":"journal-article","created":{"date-parts":[[2013,6,16]],"date-time":"2013-06-16T22:58:51Z","timestamp":1371423531000},"page":"476-486","source":"Crossref","is-referenced-by-count":271,"title":["Association between severe eczema in children and multiple comorbid conditions and increased healthcare utilization"],"prefix":"10.1111","volume":"24","author":[{"given":"Jonathan I.","family":"Silverberg","sequence":"first","affiliation":[{"name":"Department of Dermatology Beth Israel Medical Center and St. Luke's\u2010Roosevelt Hospital Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric L.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oregon Health &amp; Sciences University Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,16]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"634","article-title":"Premiere note et observations preliminaires pour servir d'introduction a l'etude diathesques","volume":"4","author":"Besnier E","year":"1892","journal-title":"Ann Dermatol Syphiligr"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.259"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07302-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.05.042"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00391.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61953-9"},{"key":"e_1_2_9_9_1","article-title":"A long\u2010term study of safety and allergic comorbidity development in a randomized trial of pimecrolimus cream in infants with atopic dermatitis","volume":"130","author":"Hanifin JM","year":"2010","journal-title":"J Investig Dermatol"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.3.e8"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70498-6"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80390-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.01.034"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1994.tb13057.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.04.064"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/03946320110240S408"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01357.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.05.018"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.01.778"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.041"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1647"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8624"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.14"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04043.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-37-59"},{"key":"e_1_2_9_26_1","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1001\/archderm.1977.01640080064008","article-title":"Utilization of physician services for dermatologic complaints. 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