{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:13:19Z","timestamp":1778929999357,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T00:00:00Z","timestamp":1381104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infants often develop reactive airway diseases subsequent to respiratory syncytial virus (<jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>) bronchiolitis. Cysteinyl leukotrienes (cys<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>s), a class of lipid mediators that have been implicated in the pathogenesis of allergic rhinitis and asthma, are released during <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content> infection, thereby contributing to the pathogenic changes in airway inflammation. Many pediatric patients, especially those of very young age, continue to have recurrent episodes of lower airway obstruction after bronchiolitis treatment. This study was to systematically review and assessed the efficacy of montelukast for preventing wheezing in patients with post\u2010bronchiolitis. The Cochrane library, <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ub<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ed, <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ational <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>nowledge <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nfrastructure (<jats:styled-content style=\"fixed-case\">CNKI<\/jats:styled-content>) periodical databases were screened for studies related to use of montelukast for preventing post\u2010bronchiolitis wheezing published up to 31 <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2012. Randomized controlled trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s) and quasi\u2010<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s using montelukast alone as an active intervention in infants up to 24\u00a0months of age with post\u2010bronchiolitis were selected. Two authors independently extracted data and assessed trial quality using the recommendations published by the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ochrane <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ollaboration. The meta\u2010analyses were performed using the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ochrane statistical package <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ev<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>an5.0.0. Four trials, containing 1430 infants with confirmed diagnosis of acute bronchiolitis, were analyzed. Patients were administered montelukast at post\u2010bronchiolitis. Three trials showed no effects of montelukast on reducing the incidence of recurrent wheezing risk ratios (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\u00a0=\u00a00.78, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.55\u20131.12, p\u00a0=\u00a00.17), while two trials found that montelukast did reduce the frequency of recurrent wheezing and another two trials demonstrated no effects of montelukast on symptom\u2010free days. The pooled montelukast treatment group showed no significant effect on reducing the usage of corticosteroids, as compared to the placebo group (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\u00a0=\u00a01.11, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.85\u20131.44, p\u00a0=<jats:italic>\u00a0<\/jats:italic>0.45). Two trials showed that montelukast significantly decreased serum eosinophil\u2010derived neurotoxin levels, as compared to the control group. In general, the side effects of rash, vomiting, and insomnia caused by montelukast occurred in 1.5% of patients analyzed. The recent evidences indicate that montelukast may reduce the frequency of post\u2010bronchiolitic wheezing without causing significant side effects but that it has no effects on decreasing incidences of recurrent wheezing, symptom\u2010free days, or the associated usage of corticosteroid in post\u2010bronchiolitis patients. The small number of enrolled participants and the inability to pool all clinical outcomes precludes us from making solid recommendations.<\/jats:p>","DOI":"10.1111\/pai.12124","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:57:06Z","timestamp":1381543026000},"page":"143-150","source":"Crossref","is-referenced-by-count":24,"title":["Systematic review of montelukast's efficacy for preventing post\u2010bronchiolitis wheezing"],"prefix":"10.1111","volume":"25","author":[{"given":"Wan\u2010Sheng","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Pediatrics The First Affiliated Hospital of Bengbu Medical College Bengbu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The First Affiliated Hospital of Bengbu Medical College Bengbu 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