{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:29:09Z","timestamp":1775064549417,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T00:00:00Z","timestamp":1381190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Major allergenic components of peanut from distinct geographical regions are widely dispersed. Most of the diagnostic studies are from countries with a high prevalence. There have been only few reports of allergen component sensitizations from countries with a low prevalence of peanut allergy. We aimed to investigate roles of component\u2010resolved diagnostic (<jats:styled-content style=\"fixed-case\">CRD<\/jats:styled-content>) to differentiate peanut allergy and peanut tolerance in the <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sian population from a country with low prevalence of peanut allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants with peanut sensitization were enrolled. Clinical reactions were determined. Skin prick test (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>) and specific <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>) to peanut and related allergen components were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty subjects with peanut sensitization were included. The mean wheal sizes of <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> and peanut <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> were not good predictors for differentiating peanut reactions. S<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">rA<\/jats:styled-content>ra h 2 was more often found in patients with peanut allergy and anaphylaxis. s<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> to r<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ra h 9 was also more frequent in the peanut\u2010allergic group but not related to severe reactions. In the peanut\u2010tolerant group, despite positive <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> and\/or s<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> to peanut, 90% had negative s<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> to r<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ha h 2 and r<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ra h 9. Combining r<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ra h 2 and r<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ra h 9 resulted in high performance of the test with sensitivity, specificity, positive predictive value, and negative predictive value of 84%, 90%, 0.89, and 0.86, respectively. The ratio between r<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ra h 2 s<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> to peanut s<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> of 0.6 can be helpful in predicting patients who will develop severe reaction. SIgE to cross\u2010reactive carbohydrate determinants (<jats:styled-content style=\"fixed-case\">CCD<\/jats:styled-content>) was exclusively found in the peanut\u2010tolerant group (33.3% vs. 0%, p\u00a0=\u00a00.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study identifies three allergen components: r<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ra h 2, r<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ra h 9, and <jats:styled-content style=\"fixed-case\">CCD<\/jats:styled-content> as important components in the diagnosis of peanut allergy in an Asian country with low prevalence. The ratio between r<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rah h 2 s<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> to peanut s<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> can be used for predicting patients who will develop anaphylaxis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12125","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T01:32:21Z","timestamp":1408671141000},"page":"665-670","source":"Crossref","is-referenced-by-count":27,"title":["Component\u2010resolved diagnostics for the evaluation of peanut allergy in a low\u2010prevalence area"],"prefix":"10.1111","volume":"24","author":[{"given":"Narissara","family":"Suratannon","sequence":"first","affiliation":[{"name":"Department of Pediatrics Chulalongkorn University Bangkok 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