{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:14:44Z","timestamp":1775636084472,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T00:00:00Z","timestamp":1378944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Allergic rhinitis (<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>) is the most common chronic disease in children. The main objective of this study was to analyze the comorbidities and therapeutic approaches for <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> in a Spanish pediatric population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children aged 6 to 12\u00a0years with <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> were included in an observational, cross\u2010sectional, multicenter study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>1,275 children were recruited from 271 centers. <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> was intermittent in 59.5% of cases, persistent in 40.5%, seasonal in 60.7%, and perennial in 39.3% of patients. The most frequent comorbidities were conjunctivitis (53.6%), asthma (49.5%), atopic dermatitis (40%), rhinosinusitis(26.1%), otitis media (23.8%), and adenoid hypertrophy (17.3%). Overall, patients with persistent, moderate or severe, <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> were more likely to present comobidities, except for food allergy and urticaria. The most common drugs used for treatment of <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> were oral antihistamines(76%), nasal corticosteroids(49%) and a combination of both (45%). Antihistamines and nasal corticosteroids were used on demand (&lt;18\u00a0days) in 38 and 41% of patients, respectively; for 18\u201330\u00a0days in 22 and 27%; for 1\u20133\u00a0months in 31 and 29%; and for more than 3\u00a0months in 8 and 3%, respectively. Eye drops were used in 32% and specific immunotherapy in 21% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Comorbidities are frequent in children with <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>, supporting the notion of allergy as a systemic disease. Severity and duration of <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> were significantly associated with presence of most of comorbidities. The most common drugs used for <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> treatment were oral antihistamines, followed by nasal corticosteroids and a combination of both used on demand.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12126","type":"journal-article","created":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T02:40:45Z","timestamp":1379040045000},"page":"678-684","source":"Crossref","is-referenced-by-count":39,"title":["Analysis of comorbidities and therapeutic approach for allergic rhinitis in a pediatric population in Spain"],"prefix":"10.1111","volume":"24","author":[{"given":"Mar\u00eda Dolores","family":"Ib\u00e1\u00f1ez","sequence":"first","affiliation":[{"name":"Allergy Section Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Luis","family":"Valero","sequence":"additional","affiliation":[{"name":"Servei de Pneumologia i Al\u00b7l\u00e8rgia 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