{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T14:37:27Z","timestamp":1771857447242,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T00:00:00Z","timestamp":1381190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Juvenile idiopathic arthritis (JIA<\/jats:styled-content>) has three major onset types with widely varying clinical features: systemic, polyarticular and pauciarticular. We assessed natural killer (NK<\/jats:styled-content>) cell function and killer cell immunoglobulin\u2010like receptor (KIR<\/jats:styled-content>) genotypes in patients with different JIA<\/jats:styled-content> subtypes.<\/jats:p><\/jats:sec>Methods<\/jats:title>Peripheral blood samples from 72 children with active JIA<\/jats:styled-content> (systemic, 25; polyarticular, 24; pauciarticular, 23) and 25 controls were used for flow cytometric assessments of NK<\/jats:styled-content> cell count, cytotoxicity, perforin, granzyme B, interferon (IFN<\/jats:styled-content>)\u2010\u03b3 and tumour necrosis factor (TNF<\/jats:styled-content>)\u2010\u03b1. Samples from 220 children with JIA<\/jats:styled-content> (systemic, 84; polyarticular, 72; pauciarticular, 64) and 150 controls were used for KIR<\/jats:styled-content>2DS<\/jats:styled-content>2<\/jats:italic>, KIR<\/jats:styled-content>2DS<\/jats:styled-content>4<\/jats:italic>, KIR<\/jats:styled-content>3DS<\/jats:styled-content>1<\/jats:italic>, KIR<\/jats:styled-content>2DL<\/jats:styled-content>1<\/jats:italic>, KIR<\/jats:styled-content>2DL<\/jats:styled-content>2<\/jats:italic>, KIR<\/jats:styled-content>2DL<\/jats:styled-content>3<\/jats:italic> and KIR<\/jats:styled-content>3DL<\/jats:styled-content>1<\/jats:italic> typing by polymerase chain reaction with sequence\u2010specific oligonucleotide probes.<\/jats:p><\/jats:sec>Results<\/jats:title>Compared with the controls, the patients with systemic JIA<\/jats:styled-content> showed lower NK<\/jats:styled-content> cell counts, cytotoxicity and perforin and granzyme B expression (p\u00a0<\u00a00.05), while the patients with pauci\u2010 and polyarticular JIA<\/jats:styled-content> showed higher perforin and granzyme B expression (p\u00a0<\u00a00.05). NK<\/jats:styled-content> cells produced higher level of TNF<\/jats:styled-content>\u2010\u03b1 while lower level of IFN<\/jats:styled-content>\u2010\u03b3 in the pauci\u2010 and polyarticular JIA<\/jats:styled-content> groups than in the systemic JIA<\/jats:styled-content> group (p\u00a0<\u00a00.05). No significant differences in KIR<\/jats:styled-content> gene frequencies were found between the JIA<\/jats:styled-content> subgroups and healthy controls, except for the positive frequency and locus frequency of KIR<\/jats:styled-content>2DS<\/jats:styled-content>4<\/jats:italic>, which were lower in the systemic JIA<\/jats:styled-content> group.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Compared with poly\u2010 and pauciarticular JIA<\/jats:styled-content>, systemic JIA<\/jats:styled-content> is associated with decreased NK<\/jats:styled-content> cell function, more IFN<\/jats:styled-content>\u2010\u03b3 and less TNF<\/jats:styled-content>\u2010\u03b1 secretion of NK<\/jats:styled-content> cell and lower KIR<\/jats:styled-content>2DS<\/jats:styled-content>4<\/jats:italic> frequency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12130","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T01:32:21Z","timestamp":1408671141000},"page":"691-696","source":"Crossref","is-referenced-by-count":25,"title":["Natural killer cell activity and frequency of killer cell immunoglobulin\u2010like receptors in children with different forms of juvenile idiopathic arthritis"],"prefix":"10.1111","volume":"24","author":[{"given":"Juan","family":"Zhou","sequence":"first","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Tang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Ding","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfei","family":"An","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Children's Hospital of Chongqing Medical University Chongqing 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