{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T21:21:18Z","timestamp":1784582478972,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,17]],"date-time":"2013-11-17T00:00:00Z","timestamp":1384646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although urticaria is considered one of the most frequent skin diseases, reliable epidemiologic data are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the incidence and cumulative prevalence of urticaria in infants and children up to age of 10, to characterize the relationship of specific <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> levels (food and inhalative allergens) with urticaria, and to monitor the joint occurrence of urticaria with other diseases, such as eczema, asthma, and hay fever.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population consisted of two prospective birth cohort studies: the <jats:styled-content style=\"fixed-case\">LISA<\/jats:styled-content>plus and <jats:styled-content style=\"fixed-case\">GINI<\/jats:styled-content>plus studies. Information on physician\u2010diagnosed urticaria, asthma, eczema, or hay fever was collected using self\u2010administered questionnaires completed by the parents. Blood samples were drawn, and specific immunoglobulin E measured at 2 (only <jats:styled-content style=\"fixed-case\">LISA<\/jats:styled-content>plus), 6 and 10\u00a0yr of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of urticaria was approximately 1% per year of age. The cumulative prevalence of urticaria in children up to the age of 10\u00a0yr was 14.5% for boys and 16.2% for girls. Cumulative prevalence of urticaria at the age of ten was significantly (p\u00a0&lt;\u00a00.05) associated with allergic sensitization to peanut, soy, and wheat flour, but not with inhalant allergens. Both a parental history of atopy\/urticaria and the children's diagnosis of asthma, eczema, and hay fever were strongly related (p\u00a0&lt;\u00a00.0001) to the occurrence of urticaria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Urticaria is a frequent event during childhood, with highest incidence in infants and preschool children. Comorbidity with atopic disease is high.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12146","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T06:06:08Z","timestamp":1384754768000},"page":"36-42","source":"Crossref","is-referenced-by-count":42,"title":["Epidemiology of urticaria in infants and young children in <scp>G<\/scp>ermany \u2013 Results from the <scp>G<\/scp>erman <scp>LISA<\/scp>plus and <scp>GINI<\/scp>plus <scp>B<\/scp>irth <scp>C<\/scp>ohort <scp>S<\/scp>tudies"],"prefix":"10.1111","volume":"25","author":[{"given":"I.","family":"Br\u00fcske","sequence":"first","affiliation":[{"name":"Institute of Epidemiology I Helmholtz Zentrum M\u00fcnchen German Research Centre for Environmental Health Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Standl","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology I Helmholtz Zentrum M\u00fcnchen German Research Centre for Environmental Health Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Weidinger","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergy University Hospital Schleswig\u2010Holstein Campus Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Kl\u00fcmper","sequence":"additional","affiliation":[{"name":"IUF \u2013 Leibniz Research Institute for Environmental Medicine D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"IUF \u2013 Leibniz Research Institute for Environmental Medicine D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Schaaf","sequence":"additional","affiliation":[{"name":"Medical Practice for Pediatrics Bad Honnef Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Herbarth","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine and Hygiene Faculty of Medicine University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Helmholtz\u2010Centre for Environmental Research \u2013 UFZ Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"von Berg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Marien\u2010Hospital Wesel Research Institute Wesel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Berdel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Marien\u2010Hospital Wesel Research Institute Wesel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. P.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Koletzko","sequence":"additional","affiliation":[{"name":"University of Munich Medical Centre Dr. von Hauner Children's Hospital Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology I Helmholtz Zentrum M\u00fcnchen German Research Centre for Environmental Health Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"for the GINIplus and","family":"LISAplus Study Groups","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08283.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02179.x"},{"key":"e_1_2_9_4_1","first-page":"214","article-title":"Epidemiology of urticaria in Spain","volume":"14","author":"Gaig P","year":"2004","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-8707(54)90034-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03840.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/0128071-200910010-00002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.038844"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01120.x"},{"key":"e_1_2_9_10_1","volume-title":"Urticaria \u2013 Clinical, Diagnostic and Therapeutic Aspects","author":"Henz BM","year":"1998"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2006.tb00670.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00261802"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.101"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03444.x"},{"key":"e_1_2_9_15_1","unstructured":"WilkinsonL.Venn diagram using \u201cvenneuler\u201d without weights from R package \u201cvenneuler\u201dinhttp:\/\/CRAN.R-project.org\/package=venneuler. 2011."},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2340\/0001555576295297","article-title":"Acute urticaria: clinical aspects and therapeutic responsiveness","volume":"76","author":"Zuberbier T","year":"1996","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2006.tb00618.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01093.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01134.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014794"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118325"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306033282204"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01256.x"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.12146","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.12146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T23:50:49Z","timestamp":1696463449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.12146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,17]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/pai.12146"],"URL":"https:\/\/doi.org\/10.1111\/pai.12146","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,17]]}}}