{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:02:39Z","timestamp":1777705359122,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T00:00:00Z","timestamp":1384732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Beta\u2010lactam hypersensitivity (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>) is suspected in 5\u201312% of the children, but proven in only 10\u201315% of those children, based on skin and challenge tests results. In contrast, 30\u201360% of patients with cystic fibrosis (<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>) are diagnosed allergic to beta\u2010lactams, based mainly on the clinical history of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To confirm or rule out a suspected beta\u2010lactam<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>in<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>children and to determine the prevalences of suspected and confirmed beta\u2010lactam<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>in those children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Children with<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>and suspected beta\u2010lactam<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>were explored by means of skin and challenge tests with the suspected and alternate beta\u2010lactams. The results in<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>children were compared with those reported in the literature in non\u2010<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight of the 701<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>children followed in our center between 1990 and 2011 (1.14%), and 11 other children from other centers were explored for suspected beta\u2010lactam HS. Beta\u2010lactam HS was diagnosed in nine of these children (47.3%). Based on the results in the children followed in our center, the prevalence of beta\u2010lactam<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>was 0.71% (5\/701) in<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>children vs. a mean estimated prevalence of 1\u20131.5% in the general pediatric population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results contrast with those of most previous studies. Although half of the<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>children with suspected beta\u2010lactam<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>were truly allergic to beta\u2010lactams, the general prevalence of beta\u2010lactam<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>in<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>children was very low. This may result from tolerance induced by frequent and\/or prolonged treatments with beta\u2010lactams.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12154","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T08:46:25Z","timestamp":1384764385000},"page":"88-93","source":"Crossref","is-referenced-by-count":30,"title":["Beta\u2010lactam hypersensitivity in children with cystic fibrosis: a study in a specialized pediatric center for cystic fibrosis and drug allergy"],"prefix":"10.1111","volume":"25","author":[{"given":"Rania","family":"Matar","sequence":"first","affiliation":[{"name":"Department Pediatrics, Pulmonology and Allergy Service Necker\u2010Enfants Malades Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muriel","family":"Le Bourgeois","sequence":"additional","affiliation":[{"name":"Department Pediatrics, Pulmonology and Allergy Service Necker\u2010Enfants Malades Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Scheinmann","sequence":"additional","affiliation":[{"name":"Department Pediatrics, Pulmonology and Allergy Service Necker\u2010Enfants Malades Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"de Blic","sequence":"additional","affiliation":[{"name":"Department Pediatrics, Pulmonology and Allergy Service Necker\u2010Enfants Malades Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Ponvert","sequence":"additional","affiliation":[{"name":"Department Pediatrics, Pulmonology and Allergy Service Necker\u2010Enfants Malades Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.7.849"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2007.00702.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2429"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02219-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00280.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70499-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3178"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01169.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.106.4.1124"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.1998.00197.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2006.11.001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.027953"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:23:1:123"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/13.Supplement_7.S608"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1980.tb01727.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-2-10"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1398-9995.2004.00678.x","article-title":"Diagnosis of nonimmediate reactions to betalactam antibiotics","volume":"59","author":"Romano A","year":"2004","journal-title":"Allergy"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.0105-4538.2001.00001.x-i8","article-title":"General considerations for skin test procedures in the diagnosis of drug hypersensitivity","volume":"57","author":"Brockow K","year":"2002","journal-title":"Allergy"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200106000-00007"},{"key":"e_1_2_9_21_1","unstructured":"LemoineF LebranchuY BoyerO B\u00e9n\u00e9MC TaoufikY.Immunit\u00e9 adaptative: lymphocytes T r\u00e9gulateurs et notion de tolerance. In: Immunologie Fondamentale ASSIM (01\/10\/2011):http:\/\/www.assim.refer.org\/raisil\/raisil\/L02.html"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/inf.1975.7.issue-1.04"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-007-8010-9"},{"key":"e_1_2_9_24_1","first-page":"68","article-title":"Amoxicillin\u2010induced flare in patients with DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms","volume":"20","author":"Mardivirin L","year":"2010","journal-title":"Eur J Dermatol"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01142.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1996.tb00100.x"},{"key":"e_1_2_9_27_1","first-page":"30","article-title":"Booster responses in the study of allergic reactions to betalactam antibiotics","volume":"6","author":"Lopez\u2010Serrano MC","year":"1996","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.07027.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03887.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-11-956"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.10.032"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.12154","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.12154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T15:55:11Z","timestamp":1716134111000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.12154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,18]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/pai.12154"],"URL":"https:\/\/doi.org\/10.1111\/pai.12154","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,18]]}}}