{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:35:00Z","timestamp":1791200100825,"version":"4.2.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T00:00:00Z","timestamp":1386892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hypersensitivity reactions to beta\u2010lactams (<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>s) are often reported in children, with amoxicillin and, to a lesser extent, cephalosporins being the most frequent drugs involved. Although many of these children are considered to be allergic, a careful evaluation only confirms a low percentage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To analyse the clinical data, sensitization profile and diagnostic methods used in a large group of children with a clinical history of hypersensitivity reactions to <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included children aged 1\u201314\u00a0yr with symptoms suggestive of hypersensitivity to <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>s from January 2006\u2013December 2012. Diagnosis was confirmed from a clinical history, specific <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> determination, skin testing and, if necessary, a drug provocation test (<jats:styled-content style=\"fixed-case\">DPT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of a total of 783 patients studied, only 62 (7.92%) were confirmed as being allergic, 9 (14.52%) with immediate and 53 (85.48%) with non\u2010immediate reactions. In those with immediate reactions, 2 (22.22%) were diagnosed by <jats:italic>in vitro<\/jats:italic> test, 2 (22.22%) by skin testing and 5 (55.56%) by <jats:styled-content style=\"fixed-case\">DPT<\/jats:styled-content>; in those with non\u2010immediate reactions, 2 (3.77%) were diagnosed by skin testing and 51 (96.23%) by <jats:styled-content style=\"fixed-case\">DPT<\/jats:styled-content>. In all cases, <jats:styled-content style=\"fixed-case\">DPT<\/jats:styled-content> was positive to the culprit drug (29 <jats:styled-content style=\"fixed-case\">AX<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CLV<\/jats:styled-content>, 26 <jats:styled-content style=\"fixed-case\">AX<\/jats:styled-content>, 1 cefixime and 1 cefaclor), and the most usual symptoms were exanthema in 43 cases, urticaria in 12, urticaria\u2013angio\u2010oedema in 1 and erythema in 1 case.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After an allergological work\u2010up, over 90% of the children evaluated were finally confirmed as tolerant to <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>s. Most reactions were of the non\u2010immediate type, and <jats:styled-content style=\"fixed-case\">DPT<\/jats:styled-content> was an essential tool for diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12155","type":"journal-article","created":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T06:56:15Z","timestamp":1386917775000},"page":"80-87","source":"Crossref","is-referenced-by-count":137,"title":["Diagnostic evaluation of hypersensitivity reactions to beta\u2010lactam antibiotics in a large population of children"],"prefix":"10.1111","volume":"25","author":[{"given":"Maria A.","family":"Zambonino","sequence":"first","affiliation":[{"name":"Paediatric Service Carlos Haya Hospital M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis","family":"Corzo","sequence":"additional","affiliation":[{"name":"Paediatric Service Carlos Haya Hospital M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candelaria","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Paediatric Service Carlos Haya Hospital M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Requena","sequence":"additional","affiliation":[{"name":"Paediatric Service Carlos Haya Hospital M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Ariza","sequence":"additional","affiliation":[{"name":"Paediatric Service Carlos Haya Hospital M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristobalina","family":"Mayorga","sequence":"additional","affiliation":[{"name":"Paediatric Service Carlos Haya Hospital M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Urda","sequence":"additional","affiliation":[{"name":"Paediatric Service Carlos Haya Hospital M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Blanca","sequence":"additional","affiliation":[{"name":"Allergy Service Carlos Haya Hospital\u2010 IBIMA M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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