{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:13:35Z","timestamp":1791274415493,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T00:00:00Z","timestamp":1385942400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Colombian Government (Colciencias)","award":["325-2006"],"award-info":[{"award-number":["325-2006"]}]},{"name":"Colombian Government (Colciencias)","award":["515-2012"],"award-info":[{"award-number":["515-2012"]}]},{"name":"Fundemeb"},{"name":"Christine K\u00fchne Center for Allergy Research and Education"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>There are few birth cohort studies analyzing I<\/jats:styled-content>gE<\/jats:styled-content> sensitization in the tropics.<\/jats:p><\/jats:sec>Objectives<\/jats:title>We aimed to describe the evolution of total I<\/jats:styled-content>gE<\/jats:styled-content> and specific I<\/jats:styled-content>gE<\/jats:styled-content> responses to house\u2010dust mite (HDM<\/jats:styled-content>) allergens and Ascaris in a birth cohort (R<\/jats:styled-content>isk F<\/jats:styled-content>actors for A<\/jats:styled-content>sthma and A<\/jats:styled-content>llergy in the T<\/jats:styled-content>ropics, FRAAT<\/jats:styled-content>), analyzing their relationships with wheezing.<\/jats:p><\/jats:sec>Methods<\/jats:title>Total and specific I<\/jats:styled-content>gE<\/jats:styled-content> were measured by I<\/jats:styled-content>mmunoC<\/jats:styled-content>ap in mothers and children at four different time points (S<\/jats:styled-content>1\u2013S<\/jats:styled-content>4) between 0 and 42\u00a0months. Parasite infection was evaluated by stool examination.<\/jats:p><\/jats:sec>Results<\/jats:title>Maternal total I<\/jats:styled-content>gE<\/jats:styled-content> (aOR<\/jats:styled-content>: 2.43, 95% CI<\/jats:styled-content>: 1.09\u20135.43; p\u00a0=\u00a00.03) and socio\u2010demographic factors were associated with high cord blood (CB<\/jats:styled-content>) total I<\/jats:styled-content>gE<\/jats:styled-content>. High CB<\/jats:styled-content> total I<\/jats:styled-content>gE<\/jats:styled-content> was positively associated with higher B<\/jats:styled-content>lomia tropicalis<\/jats:italic> and A<\/jats:styled-content>scaris\u2010specific I<\/jats:styled-content>gE<\/jats:styled-content> values during lifetime, but protected from recurrent wheezing (aOR<\/jats:styled-content>: 0.26, 95% CI<\/jats:styled-content>: 0.08\u20130.88, p\u00a0=\u00a00.03). Prevalence rates of I<\/jats:styled-content>gE<\/jats:styled-content> sensitization were high; at around 3\u00a0yr old, they were 33.3, 18.6, and 26.5% for B<\/jats:styled-content>.\u00a0tropicalis<\/jats:italic>, D<\/jats:styled-content>ermatophagoides pteronyssinus,<\/jats:italic> and A<\/jats:styled-content>scaris, respectively. Indicators of unhygienic conditions were risk factors for HDM<\/jats:styled-content> and A<\/jats:styled-content>scaris sensitization in children. A weak statistical association between B<\/jats:styled-content>.\u00a0tropicalis\u2010<\/jats:italic>specific I<\/jats:styled-content>gE<\/jats:styled-content> and ever wheezing was found (aOR<\/jats:styled-content>: 1.47 95% CI<\/jats:styled-content>: 1.00\u20132.28, p\u00a0=\u00a00.05).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In a socioeconomically deprived community from the tropics, sensitization to HDM<\/jats:styled-content> allergens was very frequent at early life, especially to B<\/jats:styled-content>.\u00a0tropicalis<\/jats:italic>. In contrast to expected according to the hygiene hypothesis, unhygienic\/poverty conditions were risk factors for allergen sensitization. High CB<\/jats:styled-content> total I<\/jats:styled-content>gE<\/jats:styled-content> levels were a risk factor for allergen sensitization but protected from recurrent wheezing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12161","type":"journal-article","created":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T02:26:54Z","timestamp":1386037614000},"page":"788-797","source":"Crossref","is-referenced-by-count":30,"title":["Early life I<\/scp>gE<\/scp> responses in children living in the tropics: A prospective analysis"],"prefix":"10.1111","volume":"24","author":[{"given":"Josefina","family":"Zakzuk","sequence":"first","affiliation":[{"name":"Institute for Immunological Research University of Cartagena Cartagena Colombia"},{"name":"Foundation for the Development of Medical and Biological Sciences (Fundemeb) Cartagena Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Acevedo","sequence":"additional","affiliation":[{"name":"Institute for Immunological Research University of Cartagena Cartagena Colombia"},{"name":"Foundation for the Development of Medical and Biological Sciences (Fundemeb) Cartagena Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Cifuentes","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Christine Kuehne Center for Allergy Research and Education (CK\u2010CARE) Munich University of Technology (TUM) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Bornacelly","sequence":"additional","affiliation":[{"name":"Institute for Immunological Research University of Cartagena Cartagena Colombia"},{"name":"Foundation for the Development of Medical and Biological Sciences (Fundemeb) Cartagena Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Institute for Immunological Research University of Cartagena Cartagena Colombia"},{"name":"Foundation for the Development of Medical and Biological Sciences (Fundemeb) Cartagena Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velky","family":"Ahumada","sequence":"additional","affiliation":[{"name":"Institute for Immunological Research University of Cartagena Cartagena Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Ring","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Christine Kuehne Center for Allergy Research and Education (CK\u2010CARE) Munich University of Technology (TUM) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Ollert","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Christine Kuehne Center for Allergy Research and Education (CK\u2010CARE) Munich University of Technology (TUM) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Caraballo","sequence":"additional","affiliation":[{"name":"Institute for Immunological Research University of Cartagena Cartagena Colombia"},{"name":"Foundation for the Development of Medical and Biological Sciences (Fundemeb) Cartagena Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00219302"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000218120"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-9-13"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70315-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70071-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-12-13"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00927.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.113523"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","unstructured":"Rueda de ViveroF EspinosaA.Will today's poor be tomorrow's poor? 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