{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:13:00Z","timestamp":1770739980289,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T00:00:00Z","timestamp":1385942400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CAPES (Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior, Bras\u00edlia, DF)"},{"name":"CNPq (Conselho Nacional de Pesquisa e Desenvolvimento, Bras\u00edlia, DF)"},{"name":"FAPEMIG (Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais, Belo Horizonte, MG)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>There have been no data on sublingual immunotherapy (SLIT<\/jats:styled-content>) in B<\/jats:styled-content>razilian patients sensitized to house dust mites. This study aimed to evaluate the mucosal\/systemic antibody response changes and clinical efficacy after SLIT<\/jats:styled-content> using D<\/jats:styled-content>ermatophagoides pteronyssinus<\/jats:italic> (Dpt) allergens with or without bacterial extracts in mite\u2010allergic B<\/jats:styled-content>razilian children.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients with allergic rhinitis and asthma were selected for a double\u2010blind, placebo\u2010controlled trial randomized to three groups: DPT<\/jats:styled-content> (Dpt extract, n\u00a0=\u00a034), DPT<\/jats:styled-content>+MRB<\/jats:styled-content> (Dpt plus mixed respiratory bacterial extracts, n\u00a0=\u00a036), and Placebo (n\u00a0=\u00a032). Total symptom and medication scores for rhinitis\/asthma, skin prick test (SPT<\/jats:styled-content>) to Dpt, and measurements of Dpt\u2010, Der p 1\u2010, Der p 2\u2010specific serum IgE<\/jats:styled-content>, IgG<\/jats:styled-content>4, IgG<\/jats:styled-content>1, and specific salivary IgA<\/jats:styled-content> were evaluated at baseline and after 12 and 18\u00a0months of treatment.<\/jats:p><\/jats:sec>Results<\/jats:title>A significant long\u2010term decline in total symptom\/medication scores was observed only in active groups (DTP<\/jats:styled-content> and DPT<\/jats:styled-content>+MRB<\/jats:styled-content>). There was no significant change in SPT<\/jats:styled-content> results in all groups. SLIT<\/jats:styled-content> using Dpt allergen alone induced increased levels of serum IgG<\/jats:styled-content>4 to Dpt, Der p 1, and Der p 2, serum IgG<\/jats:styled-content>1 and salivary IgA<\/jats:styled-content> to Dpt and Der p 1. SLIT<\/jats:styled-content> with Dpt plus bacterial extracts was able to decrease IgE<\/jats:styled-content> levels, particularly to Der p 2, to increase salivary IgA<\/jats:styled-content> levels to Der p 1, but had no changes on specific IgG<\/jats:styled-content>4 and IgG<\/jats:styled-content>1 levels.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>All children undergoing SLIT<\/jats:styled-content> showed clinical improvement, but a long\u2010term reduction in symptom\/medication scores with modulation of mucosal\/systemic antibody responses were seen only in active groups (DPT<\/jats:styled-content> and DPT<\/jats:styled-content>+MRB<\/jats:styled-content>).<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12163","type":"journal-article","created":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T02:26:38Z","timestamp":1386037598000},"page":"752-761","source":"Crossref","is-referenced-by-count":20,"title":["Modulation of mucosal\/systemic antibody response after sublingual immunotherapy in mite\u2010allergic children"],"prefix":"10.1111","volume":"24","author":[{"given":"Meimei G. 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