{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:33:38Z","timestamp":1782441218273,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T00:00:00Z","timestamp":1386547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the effects of pregnancy and early events in the newborn on the risk of subsequent atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) during the first year of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>This is a prospective multicenter cohort study of newborns during the first year of life. Newborns identified on random days in three obstetrics departments in the area of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ergamo, <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ombardy, <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>orthern <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>taly, were eligible. At baseline, the mothers were interviewed by medical staff during their stay in hospital after delivery. At 6 and 12\u00a0months after delivery, a postal questionnaire was sent to the parents. Relative risks were calculated with and without adjustment by multiple regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1081 newborns entered the study: 796 (74%) parents answered the 12\u2010month questionnaire. Hundred and thirty\u2010eight (17%) reported a diagnosis of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> at 6\u00a0months and 222 (28%) at 12\u00a0months. Parental history of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and\/or asthma was associated with an increased risk of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.5, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.1\u20132.0). Birth weight was slightly associated with an increased risk of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\"> RR<\/jats:styled-content> 1.04, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.001\u20131.08 (continuous variable, increment of 100 grams). No association emerged between breast feeding, smoking, and risk of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study in an Italian offspring cohort points to family history of atopic diseases and body weight at birth as relevant risk factors. The study was unable to document associations with other perinatal factors particularly breast feeding and parental smoking in the perinatal period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12165","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T06:32:52Z","timestamp":1386570772000},"page":"43-50","source":"Crossref","is-referenced-by-count":32,"title":["Perinatal factors and the risk of atopic dermatitis: A cohort study"],"prefix":"10.1111","volume":"25","author":[{"given":"Fabio","family":"Parazzini","sequence":"first","affiliation":[{"name":"Centro Studi GISED Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Cipriani","sequence":"additional","affiliation":[{"name":"Dipartimento Materno\u2010Infantile Fondazione IRCCS Ca' Granda \u2010 Ospedale Maggiore Policlinico Universit\u00e0 degli Studi di Milano Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Zinetti","sequence":"additional","affiliation":[{"name":"Centro Studi GISED Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane","family":"Chatenoud","sequence":"additional","affiliation":[{"name":"IRCCS\u2010 Istituto di Ricerche Farmacologiche Mario Negri Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Frigerio","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Ospedali Riuniti di Bergamo Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Amuso","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Ospedale Pesenti Fenaroli Alzano Lombardo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Ciammella","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Azienda Ospedaliera Bolognini Seriate Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Di Landro","sequence":"additional","affiliation":[{"name":"Centro Studi GISED Bergamo Italy"},{"name":"Department of Gynecology and Obstetrics Azienda Ospedaliera Ospedale Treviglio Caravaggio Treviglio Caravaggio Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Naldi","sequence":"additional","affiliation":[{"name":"Centro Studi GISED Bergamo Italy"},{"name":"Department of Dermatology Ospedali Riuniti di Bergamo Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.042"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2011.3.2.67"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.01.778"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1157\/13120394"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08530.x"},{"key":"e_1_2_6_7_1","volume-title":"Statistical Methods in Cancer Research. 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