{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:58:15Z","timestamp":1792645095757,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T00:00:00Z","timestamp":1392249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Infants born prematurely are often treated with supplemental oxygen, which can increase their risk for airway hyper\u2010responsiveness (<jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content>), asthma, reduced lung function, and altered responses to respiratory viral infections later in childhood. Likewise, exposure of newborn mice to hyperoxia alters baseline pulmonary mechanics and the host response to influenza A virus infection in adult mice. Here, we use this mouse model to test the hypothesis that neonatal hyperoxia also promotes <jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content> and exacerbated allergen\u2010induced symptoms in adult mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Baseline lung mechanics and <jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content> measured by methacholine provocation were assessed in adult male and female mice exposed to room air or 100% oxygen (hyperoxia) between post\u2010natal days 0\u20134. <jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content> and lung inflammation were evaluated after adult female mice were sensitized with ovalbumin (<jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content>) plus alum and challenged with aerosolized <jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline lung compliance increased and resistance decreased in adult female, but not male, mice exposed to neonatal hyperoxia compared with siblings exposed to room air. Neonatal hyperoxia significantly enhanced methacholine\u2010induced <jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content> in female mice, but did not affect allergen\u2010induced <jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content> to methacholine or lung inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increased incidence of <jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content> and asthma is reported in children born prematurely and exposed to supplemental oxygen. Our findings in adult female mice exposed to hyperoxia as neonates suggest that this <jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content> reported in children born prematurely may reflect non\u2010atopic wheezing due to intrinsic structural changes in airway development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12206","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T08:00:46Z","timestamp":1392278446000},"page":"180-186","source":"Crossref","is-referenced-by-count":26,"title":["Neonatal oxygen exposure alters airway hyper\u2010responsiveness but not the response to allergen challenge in adult mice"],"prefix":"10.1111","volume":"25","author":[{"given":"Jean F.","family":"Regal","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences University of Minnesota Medical School Duluth MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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