{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:11:49Z","timestamp":1778875909893,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:00:00Z","timestamp":1392854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The association between birthweight and asthma, eczema and rhinoconjunctivitis is conflicting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine the association between birthweight and symptoms of asthma, eczema and rhinoconjunctivitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Parents or guardians of children aged 6\u20137\u00a0yr completed written questionnaires about symptoms of asthma, rhinoconjunctivitis and eczema, and several risk factors, including birthweight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 162,324 children from 60 centres in 26 countries. Low birthweight (&lt;2.5\u00a0kg) was associated with an increased risk of symptoms of asthma (current wheeze odds ratio\u00a0=\u00a01.20; 95% confidence interval\u00a0=\u00a01.12\u20131.30). Low birthweight was associated with a lower risk of eczema ever. Low birthweight was not associated with rhinoconjunctivitis. Large babies (birthweight \u22654.5\u00a0kg) were not associated with any of these outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study has confirmed that low birthweight is a risk factor for symptoms of asthma, but not for rhinoconjunctivitis. The findings for eczema are equivocal.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12210","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T17:18:08Z","timestamp":1393262288000},"page":"264-270","source":"Crossref","is-referenced-by-count":17,"title":["Birthweight and the risk of atopic diseases: the ISAAC Phase III study"],"prefix":"10.1111","volume":"25","author":[{"given":"Edwin A.","family":"Mitchell","sequence":"first","affiliation":[{"name":"Department of Paediatrics: Child and Youth Health Faculty of Medical and Health Sciences The University of Auckland Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadd","family":"Clayton","sequence":"additional","affiliation":[{"name":"Department of Paediatrics: Child and Youth Health Faculty of Medical and Health Sciences The University of Auckland Auckland New 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