{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:41:18Z","timestamp":1761986478926},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T00:00:00Z","timestamp":1402272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Specific instruments for health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQoL<\/jats:styled-content>) assessment in adolescents with rhinoconjunctivitis or asthma are available. None of them evaluates rhinitis and asthma together, although they often coexist. Our aim was to validate a <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL questionnaire for adolescents with rhinoconjunctivitis, asthma, or both.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A pool of 38 items covering the main symptoms and problems related to respiratory allergy was generated based on literature review, clinical experience, and unstructured interviews to 54 adolescents. The items were randomly listed and presented to 88 consecutive outpatients (44 M; mean age 15.2\u00a0\u00b1\u00a03.1). Patients had to indicate which item they had experienced and, for each selected item, its importance on a four\u2010point scale (1\u00a0=\u00a0not at all; 4\u00a0=\u00a0very much). Twelve items were excluded from the list, because of low importance. In the validation phase, 102 patients (54 M; mean age 15.36\u00a0\u00b1\u00a01.12) completed the <jats:styled-content style=\"fixed-case\">KINDL<\/jats:styled-content>, a generic <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL tool, and the new questionnaire (<jats:styled-content style=\"fixed-case\">RHINASTHMA<\/jats:styled-content>\u2010Adolescents).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Factor analysis revealed a five\u2010dimensional structure, which explained up to 71.23% of the total variance. Association between <jats:styled-content style=\"fixed-case\">RHINASTHMA<\/jats:styled-content>\u2010Adolescents and <jats:styled-content style=\"fixed-case\">KINDL<\/jats:styled-content> scores was all in the expected direction. Internal consistency for the extracted factors was satisfactory: Upper Airways (0.81), Lower Airways (0.89), Emotions (0.85), Social Relationship (0.79), Daily life management (0.74). Reliability was good for all factors with a Pearson coefficient ranged from 0.91 to 0.99.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">RHINASTHMA<\/jats:styled-content>\u2010Adolescents is the first tool for evaluating <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL in patients with rhinitis and\/or asthma. It provides a simple assessment and met the standards of validity, internal consistency, and reliability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12242","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T03:34:47Z","timestamp":1402371287000},"page":"450-455","source":"Crossref","is-referenced-by-count":21,"title":["RHINASTHMA\u2010Adolescents: a new quality of life tool for patients with respiratory allergy"],"prefix":"10.1111","volume":"25","author":[{"given":"Stefania","family":"La Grutta","sequence":"first","affiliation":[{"name":"Institute of Biomedicine and Molecular Immunology National Research Council Palermo Italy"},{"name":"Department of Science for Health Promotion and Mother and Child University of Palermo Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Landi","sequence":"additional","affiliation":[{"name":"National System of Pediatric Primary Care Asl TO 1 Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulvio","family":"Braido","sequence":"additional","affiliation":[{"name":"Allergy &amp; 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Respiratory Diseases Clinic \u2013 DIMI \u2013 University of Genoa IRCCS AOU San Martino\u2010IST Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Baiardini","sequence":"additional","affiliation":[{"name":"Allergy &amp; Respiratory Diseases Clinic \u2013 DIMI \u2013 University of Genoa IRCCS AOU San Martino\u2010IST Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,9]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"11","volume-title":"Quality of Life and Pharmacoeconomics in Clinical Trials","author":"Schipper H","year":"1990"},{"key":"e_1_2_5_3_1","unstructured":"National Institutes of Health NH Lung and Blood Institute:Global Strategy for asthma management and prevention (Updated 2011): Global Initiative for Asthma (GINA) 2011 http:\/\/www.ginasthma.org"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02383.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00275.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-4-79"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90349-2"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.17100520"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199311000-00010"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.55.59"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.02953.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02786.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01932.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00079.x"},{"key":"e_1_2_5_17_1","first-page":"38","volume-title":"Comprehensive Adolescent Health Care","author":"Hamburg BA","year":"1998"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-8-199304150-00009"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008853819715"},{"key":"e_1_2_5_20_1","volume-title":"Questionnaire for Measuring Health\u2010 Related Quality of Life in Children and Adolescents","author":"Ravens\u2010Sieberer U","year":"2000"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-008-1014-z"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-6712.2005.00326.x"},{"key":"e_1_2_5_23_1","volume-title":"Practical Statistics for Medical Research","author":"Altman DG","year":"2001"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2006.03.012"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.4081\/monaldi.2005.621"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031178"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01097.x"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.12242","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.12242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:57:00Z","timestamp":1695542220000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.12242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,9]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/pai.12242"],"URL":"https:\/\/doi.org\/10.1111\/pai.12242","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,9]]}}}