{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T18:35:34Z","timestamp":1751481334260},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,11,9]],"date-time":"2014-11-09T00:00:00Z","timestamp":1415491200000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of breast milk feeding on susceptibility to asthma in childhood is highly controversial, due in part to failure of the majority of studies in the area to adequately account for key confounders exemplified by respiratory infection history, plus the effects of recall bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>As part of a prospective cohort study on the role of respiratory infections in asthma development in high\u2010risk children, we measured the concentration of a panel of anti\u2010infective proteins in maternal milk samples and analyzed associations between these and subsequent atopy\u2010, infection\u2010, and asthma\u2010related outcomes prospectively to age 10\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed significant but transient inverse associations between the concentration of milk proteins and susceptibility to upper respiratory infections in year 1 only, and parallel but positive transient associations with early lower respiratory infections and atopy. No associations were seen with asthma\u2010related outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Breast milk feeding may influence the expression of inflammatory symptoms associated with respiratory infections and atopy in early life, but these effects appear to be inconsistent and transient. The heterogeneous nature of breast\u2010feeding effects suggests it may influence systemic immunoinflammatory function at several different levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12265","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T16:30:28Z","timestamp":1410798628000},"page":"544-551","source":"Crossref","is-referenced-by-count":14,"title":["Anti\u2010infective proteins in breast milk and asthma\u2010associated phenotypes during early childhood"],"prefix":"10.1111","volume":"25","author":[{"given":"Guicheng","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Public Health Curtin University Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching Tat","family":"Lai","sequence":"additional","affiliation":[{"name":"School of Chemistry and Biochemistry Faculty of Science The University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Hartmann","sequence":"additional","affiliation":[{"name":"School of Chemistry and Biochemistry Faculty of Science The University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy H.","family":"Oddy","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merci M. H.","family":"Kusel","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D.","family":"Sly","sequence":"additional","affiliation":[{"name":"Queensland Children's Medical Research Institute University of Queensland Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick G.","family":"Holt","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth WA Australia"},{"name":"Queensland Children's Medical Research Institute University of Queensland Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2012.09.010"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00103602"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.319.7213.815"},{"key":"e_1_2_5_5_1","unstructured":"2013 National Health and Medical Research Council of Australia Eat for health: Australian dietary guidelines N55;36"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-4242-8_7"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.08.039"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.07.028"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10588.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11025-7"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.3.192"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03925.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.11.017"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.11.021"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.12.018"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00193310"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.12.669"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000226912.88900.a3"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(80)90011-1"},{"key":"e_1_2_5_20_1","volume-title":"Practice and Theory of Immunoessays","author":"Tijssen P","year":"1985"},{"key":"e_1_2_5_21_1","first-page":"208","article-title":"Human breast milk immunology: a review","volume":"51","author":"Paramasivam K","year":"2006","journal-title":"Int J Fertil Womens Med"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1989.tb11064.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199704000-00005"},{"key":"e_1_2_5_24_1","first-page":"410","article-title":"The development of allergy in infants of allergic parents: a prospective study concerning the role of heredity","volume":"37","author":"Kaufman HS","year":"1976","journal-title":"Ann Allergy"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2075"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/08830180009088505"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1995.tb00261.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1995.tb00250.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(98)80008-X"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6710.1259"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2768"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1992.tb00135.x"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)05104-6"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2003.07.001"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.3.646"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1995.tb13567.x"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00340.x"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7139.1236"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.12265","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.12265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:36:19Z","timestamp":1695569779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.12265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/pai.12265"],"URL":"https:\/\/doi.org\/10.1111\/pai.12265","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}