{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:58:33Z","timestamp":1789372713866,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,11,9]],"date-time":"2014-11-09T00:00:00Z","timestamp":1415491200000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence of food allergy in South Africa is unknown, but previously thought to be rare in black South Africans. This study aimed to determine the prevalence of, and risk factors for, IgE\u2010mediated food allergy in South African children with atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>This was a prospective, observational study in a paediatric university hospital in Cape Town. Children with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, aged 6\u00a0months to 10\u00a0yrs, were randomly recruited from the dermatology clinic. They were assessed for sensitization and allergy by questionnaire, skin prick tests, Immuno Solid Phase Allergen Chip (<jats:styled-content style=\"fixed-case\">ISAC<\/jats:styled-content>) test and incremental food challenges.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>100 participants (59 black Africans and 41 of mixed race) were enrolled, median age 42\u00a0months. There were high overall rates of food sensitization (66%) and food allergy (40%). Egg (25%) and peanut (24%) were the most common allergies. Black participants had comparable sensitization (69% vs. 61%) but lower allergy rates (34% vs. 46%) than mixed race participants. This was especially evident for peanut allergy (15% Blacks vs. 37% mixed race allergic to peanut, p\u00a0=\u00a00.01). Early\u2010onset <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> (&lt;6\u00a0months), severe eczema, and young age &lt;2\u00a0yrs were significant risk factors for food allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of food allergy is unexpectedly high in South African children with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, and comparable with food allergy rates in patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> in developed countries. There are ethnic differences, with significantly lower peanut allergy rates in Blacks compared to mixed race patients. These results are not generalizable to an unselected South African population, which requires further study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12270","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T08:05:07Z","timestamp":1410249907000},"page":"572-579","source":"Crossref","is-referenced-by-count":65,"title":["Food allergy in South African children with atopic dermatitis"],"prefix":"10.1111","volume":"25","author":[{"given":"Claudia L.","family":"Gray","sequence":"first","affiliation":[{"name":"Division of Allergology Red Cross War Memorial Children's Hospital Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Levin","sequence":"additional","affiliation":[{"name":"Division of Allergology Red Cross War Memorial Children's Hospital Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Zar","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health Red Cross War Memorial Children's Hospital University of Cape Town Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Potter","sequence":"additional","affiliation":[{"name":"Allergy Diagnostic and Clinical Research Unit Department of Medicine Groote Schuur Hospital and University of Cape Town Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nonhlanhla P.","family":"Khumalo","sequence":"additional","affiliation":[{"name":"Division of Dermatology Red Cross War Memorial Children's Hospital Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Volkwyn","sequence":"additional","affiliation":[{"name":"Division of Allergology Red Cross War Memorial Children's Hospital Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartha","family":"Fenemore","sequence":"additional","affiliation":[{"name":"Allergy Diagnostic and Clinical Research Unit Department of Medicine Groote Schuur Hospital and University of Cape Town Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"du Toit","sequence":"additional","affiliation":[{"name":"MRM &amp; 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