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The aim of this extensive review was to summarize our present knowledge on clinical characteristics, evaluation, and management of<jats:styled-content style=\"fixed-case\">HSR<\/jats:styled-content>to<jats:styled-content style=\"fixed-case\">NBLA<\/jats:styled-content>s in children based on the literature published between 1980 and 2013.<jats:styled-content style=\"fixed-case\">NBLA<\/jats:styled-content>s have been reported to induce a wide spectrum of<jats:styled-content style=\"fixed-case\">HSR<\/jats:styled-content>s from mild eruptions to severe, and sometimes fatal, systemic drug reactions, especially in some high\u2010risk groups. The diagnosis relied upon history and remained unconfirmed by allergological tests in most of the cases. Obtaining a detailed history is valuable in the diagnosis of suspected reactions to<jats:styled-content style=\"fixed-case\">NBLA<\/jats:styled-content>s. Diagnostic<jats:italic>in vivo<\/jats:italic>and<jats:italic>in vitro<\/jats:italic>tests for<jats:styled-content style=\"fixed-case\">NBLA<\/jats:styled-content>s lack validation, which makes the diagnosis challenging. The definitive diagnosis of<jats:styled-content style=\"fixed-case\">NBLA<\/jats:styled-content>hypersensitivity frequently depends upon drug provocation tests. Studies including children showed that only 7.8 to 36% of suspected immediate and delayed<jats:styled-content style=\"fixed-case\">HSR<\/jats:styled-content>s to<jats:styled-content style=\"fixed-case\">NBLA<\/jats:styled-content>s could be confirmed by skin and\/or provocation tests. Therefore, a standardized diagnostic approach and management strategy should be developed and employed for pediatric patients in the evaluation of suspected<jats:styled-content style=\"fixed-case\">HSR<\/jats:styled-content>s to<jats:styled-content style=\"fixed-case\">NBLA<\/jats:styled-content>s, some of which may be critical and unreplaceable in certain clinical situations.<\/jats:p>","DOI":"10.1111\/pai.12273","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T08:06:03Z","timestamp":1410249963000},"page":"534-543","source":"Crossref","is-referenced-by-count":43,"title":["Hypersensitivity reactions to non\u2010betalactam antibiotics in children: An extensive review"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1999-6496","authenticated-orcid":false,"given":"Semanur","family":"Kuyucu","sequence":"first","affiliation":[{"name":"Department of Pediatric Allergy and Immunology Mersin University, Faculty of 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