{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T13:09:52Z","timestamp":1775135392531,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T00:00:00Z","timestamp":1413158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"German Research Council","award":["BR 1704\/3-1"],"award-info":[{"award-number":["BR 1704\/3-1"]}]},{"name":"German Research Council","award":["BR1704\/3"],"award-info":[{"award-number":["BR1704\/3"]}]},{"name":"German Federal Ministry for Education and Research","award":["01GI0851"],"award-info":[{"award-number":["01GI0851"]}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"crossref","award":["018996"],"award-info":[{"award-number":["018996"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Integrated Program","award":["LSH-2004-1.2.5-1"],"award-info":[{"award-number":["LSH-2004-1.2.5-1"]}]},{"DOI":"10.13039\/501100008977","name":"Ulm University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008977","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Asthma is associated with diminished health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL). Particularly in adolescence, asthma may be under\u2010diagnosed and undertreated or poorly managed. Therefore, we aimed to determine the association between childhood wheezing phenotypes rather than asthma and adolescent <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL in children aged 10\u201317\u00a0yr.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed the data from two prospective population\u2010based cohort studies (n\u00a0=\u00a0604 and n\u00a0=\u00a01804) conducted in southern Germany with baseline assessments in 2000 and 2006 and follow\u2010ups at frequent intervals. Parent\u2010reported wheeze was categorized into never, early transient, persistent, and late\u2010onset wheeze. We assessed child\u2010reported <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL in seven scales using the validated <jats:styled-content style=\"fixed-case\">KINDL<\/jats:styled-content>\u2010R. Multivariate linear regression models were computed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants with late\u2010onset wheeze had significantly lower values in all <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL scales, but physical well\u2010being compared to never wheezers. Early transient wheeze was negatively associated with three <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL scales only (family, school, and total). These effects were confined to the oldest age group (\u226513.5\u00a0yr) in one study. Persistent wheeze was not associated with <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In teenagers, late\u2010onset wheezers seem to be particularly vulnerable for impairments in psychosocial aspects of health\u2010related quality of life. They may therefore require particular attention with regard to education about asthma management and potentially family\u2010based psychosocial intervention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12280","type":"journal-article","created":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T09:27:01Z","timestamp":1410946021000},"page":"781-787","source":"Crossref","is-referenced-by-count":13,"title":["Age\u2010specific influence of wheezing phenotypes on pre\u2010adolescent and adolescent health\u2010related quality of life"],"prefix":"10.1111","volume":"25","author":[{"given":"Stefanie","family":"Braig","sequence":"first","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry Ulm University Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Brandt","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes Department of Paediatrics and Adolescent Medicine University Medical Center Ulm Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Wabitsch","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes Department of Paediatrics and Adolescent Medicine University Medical Center Ulm Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"Florath","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Brenner","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietrich","family":"Rothenbacher","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry Ulm University Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Genuneit","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry Ulm University Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10395"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20486"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00286.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770900802074802"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000161524.37575.42"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783X-14-S4-147"},{"key":"e_1_2_6_8_1","unstructured":"Global Initiative for Asthma (GINA).Global Strategy for Asthma Management and Prevention.2012. 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