{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:34:48Z","timestamp":1791401688169,"version":"4.3.3"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T00:00:00Z","timestamp":1416441600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Early\u2010onset atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) is a particular phenotype that may convey a risk of developing multiple sensitizations to allergens but little is known about the pathway of sensitization. The aims of this study were to describe the natural history of sensitization to allergens for this phenotype and to identify the most predictive marker associated with the risk of developing sensitization to inhaled allergens in a well\u2010selected cohort of infants with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Infants with active AD were enrolled and prospectively explored for biological markers of atopy every year until the age of 6\u00a0yr. Allergic sensitization was defined as the presence of positive specific IgEs to allergens and multiple sensitizations as being sensitized to \u22652 allergens. Elevated blood eosinophilia was defined as an eosinophil blood count \u2265470 eosinophils\/mm<jats:sup>3<\/jats:sup> and elevated total IgE as a serum IgE level \u226545\u00a0kU\/l.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and twenty\u2010nine infants were included. Elevated blood eosinophilia was observed at baseline in 60 children (26.2%) and elevated total IgE in 85 (37.1%). When elevated at baseline, eosinophilia and IgE levels remained significantly higher during the follow\u2010up period. Sensitization to food allergens decreased from 58% to 34%, whereas sensitization to inhaled allergens increased over time from 17% to 67%. Initial multiple sensitizations to food allergens were the most predictive factor for the risk of developing sensitization to inhaled allergens at 6\u00a0yr (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.72 [1.68\u20138.30] p\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the early\u2010onset <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> phenotype, multiple sensitization to food allergens conveys a higher risk of sensitization to inhaled allergens than single sensitization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12287","type":"journal-article","created":{"date-parts":[[2014,10,6]],"date-time":"2014-10-06T06:57:37Z","timestamp":1412578657000},"page":"668-673","source":"Crossref","is-referenced-by-count":41,"title":["Natural history of allergic sensitization in infants with early\u2010onset atopic dermatitis: results from <scp>ORCA<\/scp> Study"],"prefix":"10.1111","volume":"25","author":[{"given":"Jocelyne","family":"Just","sequence":"first","affiliation":[{"name":"AP\u2010HP\u2010 Service d'Allergologie P\u00e9diatrique H\u00f4pital d'Enfants Armand\u2010Trousseau Paris France"},{"name":"INSERM, UMR S 1136, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique Equipe EPAR Paris France"},{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, UMR S 1136 Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique Equipe EPAR Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Deslandes\u2010Boutmy","sequence":"additional","affiliation":[{"name":"Service de biostatistique et informatique m\u00e9dicale H\u00f4pital Saint\u2010Louis, INSERM, U 717 Universit\u00e9 Paris 7 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flore","family":"Amat","sequence":"additional","affiliation":[{"name":"AP\u2010HP\u2010 Service 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