{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:51Z","timestamp":1787015991162,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T00:00:00Z","timestamp":1416528000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Glaxo Smith Kline Norway AS"},{"name":"Norwegian Dept. of Social Affairs"},{"DOI":"10.13039\/501100005416","name":"Norwegian Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009123","name":"Norwegian University of Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009123","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Siemens Medical Solutions"},{"name":"St. Olav Hospital, Trondheim, Norway"},{"name":"Tine BA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Sensitization toward allergens, as determined by skin prick test (\n SPT<\/jats:styled-content>\n ) or specific\n I<\/jats:styled-content>\n g\n E<\/jats:styled-content>\n (s\n I<\/jats:styled-content>\n g\n E<\/jats:styled-content>\n ), is a predictor for the later presence of allergy\u2010related disease (atopic eczema, allergic rhinoconjuctivitis and asthma). However, it is not known whether\n SPT<\/jats:styled-content>\n or s\n I<\/jats:styled-content>\n g\n E<\/jats:styled-content>\n should be the preferred test. The aim of this study was to compare the predictive ability of\n SPT<\/jats:styled-content>\n and s\n I<\/jats:styled-content>\n g\n E<\/jats:styled-content>\n when performed in a general population of 2\u2010yr\u2010old children.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In a prospective, longitudinal population\u2010based study of children aged 2\u20136\u00a0yr,\n SPT<\/jats:styled-content>\n and s\n I<\/jats:styled-content>\n g\n E<\/jats:styled-content>\n for nine common allergens were performed at 2\u00a0yr. Allergy\u2010related disease was evaluated by clinical examination and questionnaire at 2 and 6\u00a0yr of age (n\u00a0=\u00a0199).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Skin prick test or s\n I<\/jats:styled-content>\n g\n E<\/jats:styled-content>\n was positive in 10.6% and 21.1% in the 2\u2010yr\u2010old children, respectively. The prevalence of allergy\u2010related disease was 25.6% at 2\u00a0yr and 25.1% at 6\u00a0yr. Half of the cases at 2\u00a0yr were transient. Both\n SPT<\/jats:styled-content>\n and s\n I<\/jats:styled-content>\n g\n E<\/jats:styled-content>\n were statistically significant predictors for later allergy\u2010related disease,\n OR<\/jats:styled-content>\n \u00a0=\u00a06.5 (95% CI 2.3\u201318.6) and\n OR<\/jats:styled-content>\n \u00a0=\u00a04.1 (95%\n CI<\/jats:styled-content>\n 1.9\u20139.0), respectively. Receiver operating characteristic analysis showed that\n SPT<\/jats:styled-content>\n and s\n I<\/jats:styled-content>\n g\n E<\/jats:styled-content>\n had comparable predictive ability for atopic eczema, asthma or any allergy\u2010related disease, but s\n I<\/jats:styled-content>\n g\n E<\/jats:styled-content>\n had better ability to predict later allergic rhinoconjunctivitis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Sensitization at 2\u00a0yr may be useful predictors of allergy\u2010related disease later in childhood. The predictive ability of\n SPT<\/jats:styled-content>\n and s\n I<\/jats:styled-content>\n g\n E<\/jats:styled-content>\n were mainly comparable; however, it may be that s\n I<\/jats:styled-content>\n g\n E<\/jats:styled-content>\n is the preferred choice in young children when the aim is to predict allergic rhinoconjunctivitis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pai.12289","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T03:42:34Z","timestamp":1412826154000},"page":"691-698","source":"Crossref","is-referenced-by-count":19,"title":["The predictive value of allergen skin prick tests and\n I<\/scp>\n g\n E<\/scp>\n tests at pre\u2010school age: The\n PACT<\/scp>\n study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1236-3031","authenticated-orcid":false,"given":"Anne Dorthea","family":"R\u00f8","sequence":"first","affiliation":[{"name":"Department of Immunology and Transfusion Medicine St Olavs Hospital Trondheim University Hospital Trondheim Norway"},{"name":"Department of Public Health and General Practice Faculty of Medicine Norwegian University of Science and Technology (NTNU) Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie Rae","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Public Health and General Practice Faculty of Medicine Norwegian University of Science and Technology (NTNU) Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Storr\u00f8","sequence":"additional","affiliation":[{"name":"Department of Public Health and General Practice Faculty of Medicine Norwegian University of Science and Technology (NTNU) Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roar","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Department of Public Health and General Practice Faculty of Medicine Norwegian University of Science and Technology (NTNU) Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke","family":"Videm","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine St Olavs Hospital Trondheim University Hospital Trondheim Norway"},{"name":"Department of Laboratory Medicine Children's and Women's Health Faculty of Medicine NTNU Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbj\u00f8rn","family":"\u00d8ien","sequence":"additional","affiliation":[{"name":"Department of Public Health and General Practice Faculty of Medicine Norwegian University of Science and Technology (NTNU) Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2009.00954.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1526-0542(02)00189-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2009.00862.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02822.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.119151"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2000.00077.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118786"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.06.032"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.09.015"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2500\/108854198778557728"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03400.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12066"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1580-9"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.04046.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01502.x"},{"key":"e_1_2_7_17_1","first-page":"627","article-title":"Receiver operating characteristic (ROC) curve analysis for medical diagnostic test evaluation","volume":"4","author":"Hajian\u2010Tilaki K","year":"2013","journal-title":"Caspian J\u00a0Intern Med"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-10-443"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-123"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08530.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03300.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00090303"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4067"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.04.027"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.060"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02344.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3132\/pcrj.2008.00023"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01586.x"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.12289","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.12289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:49:22Z","timestamp":1695476962000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.12289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/pai.12289"],"URL":"https:\/\/doi.org\/10.1111\/pai.12289","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11]]}}}