{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T09:06:23Z","timestamp":1769850383600,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T00:00:00Z","timestamp":1420416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research grant of Gobierno de Navarra"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Subcutaneous immunotherapy (<jats:styled-content style=\"fixed-case\">SCIT<\/jats:styled-content>) discontinuation data in children remain scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We sought for differences in the clinical efficacy of 3 vs. 5\u00a0yr of <jats:styled-content style=\"fixed-case\">SCIT<\/jats:styled-content> in children with dust mite respiratory allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a 5\u2010yr, phase <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> prospective study. After the first year, the patients were randomized to 3 (<jats:styled-content style=\"fixed-case\">IT<\/jats:styled-content>3) or 5\u00a0yr of treatment (<jats:styled-content style=\"fixed-case\">IT<\/jats:styled-content>5). Efficacy was assessed at 3rd and 5th year by symptom and medication scores and visual analog scales (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>). Skin tests with common allergens and <jats:italic>in vitro<\/jats:italic> assessments were also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010one children (mean age: 9\u00a0yr) were randomly assigned to 3 (<jats:styled-content style=\"fixed-case\">IT<\/jats:styled-content>3: 41) or 5\u00a0yr (<jats:styled-content style=\"fixed-case\">IT<\/jats:styled-content>5: 40) of immunotherapy. After 3\u00a0years, rhinitis global scores decreased in <jats:styled-content style=\"fixed-case\">IT<\/jats:styled-content>3 (44%; p\u00a0=\u00a00.002) and in <jats:styled-content style=\"fixed-case\">IT<\/jats:styled-content>5 (50%; p\u00a0=\u00a00.001). Asthma global, symptom and medication scores decreased by 100% in <jats:styled-content style=\"fixed-case\">IT<\/jats:styled-content>3 (p\u00a0=\u00a00.001) and <jats:styled-content style=\"fixed-case\">IT<\/jats:styled-content>5 (p\u00a0=\u00a00.001). <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> scores also diminished significantly (<jats:styled-content style=\"fixed-case\">IT<\/jats:styled-content>3: 70%, p\u00a0=\u00a00.001; <jats:styled-content style=\"fixed-case\">IT<\/jats:styled-content>5: 62.5%; p\u00a0=\u00a00.001). At 5th year, global rhinitis scores were reduced an additional 30% in <jats:styled-content style=\"fixed-case\">IT<\/jats:styled-content>5 children. Comparisons between both groups did not show differences in rhinitis (p\u00a0=\u00a00.055), asthma global scores (p\u00a0=\u00a00.948) or <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> scores at 5th year. Twenty percent of IT5 (p\u00a0=\u00a00.002) and 7% of <jats:styled-content style=\"fixed-case\">IT<\/jats:styled-content>3 children (p\u00a0=\u00a00.705) developed new sensitizations. At 5th year, s<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4 determinations decreased in <jats:styled-content style=\"fixed-case\">IT<\/jats:styled-content>3 without significant variations in IT5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Three years of <jats:styled-content style=\"fixed-case\">SCIT<\/jats:styled-content> induced significant improvement in children with dust mite respiratory allergy, but a 5\u2010yr course added clinical improvement in rhinitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12296","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T12:04:59Z","timestamp":1415275499000},"page":"34-41","source":"Crossref","is-referenced-by-count":28,"title":["Optimal duration of allergen immunotherapy in children with dust mite respiratory 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