{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:29:54Z","timestamp":1790461794870,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T00:00:00Z","timestamp":1418169600000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peanut allergy (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>) management was improved by the introduction of molecular allergology, but guidelines for Mediterranean patients are lacking. We aimed at evaluating peanut component\u2010resolved diagnosis as a diagnostic and prognostic tool in children from Southern France.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 181 pediatric patients, <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> diagnosis was founded on medical history, skin prick testing, serum\u2010specific IgE to <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rachis hypogea<\/jats:italic> extract and components, Pru p 4, and plant carbohydrates, and oral food challenge. Allergen microarray was also performed in 68 of these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In peanut\u2010allergic children (n\u00a0=\u00a0117), IgE to Ara h 6 were most prevalent (64%), followed by Ara h 2 (63%), Ara h 1 (60%), and Ara h 9 (52%). Ara h 6 was the best predictor of PA. The second best predictor was the ratio of Ara h 2 IgE to peanut IgE (cutoff 0.113). Persistent childhood PA was associated with complex molecular profiles. Comparison of singleplex and microarray results showed poor concordance for Ara h 2 and Ara h 9.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ara h 6 and Ara h 2 are the best predictors of PA at diagnosis in Mediterranean pediatric patients. Ara h 1, Ara h 8, and molecular complexity are associated with PA persistence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12299","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T07:20:25Z","timestamp":1415344825000},"page":"662-667","source":"Crossref","is-referenced-by-count":52,"title":["Ara h 2 and Ara h 6 sensitization predicts peanut allergy in Mediterranean pediatric patients"],"prefix":"10.1111","volume":"25","author":[{"given":"Chantal","family":"Agabriel","sequence":"first","affiliation":[{"name":"Multidisciplinary Pediatrics Department APHM Assistance Publique H\u00f4pitaux de Marseille La Timone Hospital Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouafeh","family":"Ghazouani","sequence":"additional","affiliation":[{"name":"Immunology Laboratory APHM Assistance Publique H\u00f4pitaux de Marseille Conception Hospital Marseille 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