{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T11:30:20Z","timestamp":1779881420185,"version":"3.53.1"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T00:00:00Z","timestamp":1422316800000},"content-version":"vor","delay-in-days":57,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Austrian Science Fund Project","award":["F4615-B19"],"award-info":[{"award-number":["F4615-B19"]}]},{"name":"Austrian Science Fund Project","award":["F4605-B19"],"award-info":[{"award-number":["F4605-B19"]}]},{"name":"Medical Science Fund of the Mayor of the City of Vienna","award":["11013"],"award-info":[{"award-number":["11013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prevention of new IgE sensitizations has been described during allergen\u2010specific immunotherapy. However, prospective data using a preventive approach in very young children who would benefit most are missing. We initiated a prospective pilot study investigating the safety, immunomodulatory, and sensitization\u2010preventive effect of sublingual immunotherapy (<jats:styled-content style=\"fixed-case\">SLIT<\/jats:styled-content>) in mono\/oligoclonally sensitized, clinically asymptomatic children 2\u20135\u00a0yr of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this double\u2010blinded, randomized, placebo\u2010controlled pilot study, 31 mono\u2010\/oligosensitized children to house\u2010dust mite or grass pollen were included. <jats:styled-content style=\"fixed-case\">SLIT<\/jats:styled-content> with the respective source (n\u00a0=\u00a015) or placebo (n\u00a0=\u00a016) was applied. After dose\u2010up\u2010phase therapy was continued for 2\u00a0yr. Parents recorded clinical events, vaccinations, and drug intake in a diary. Skin prick testing and specific IgE and IgG measurements were recorded at baseline, 12 and 24\u00a0months. At the same time, allergen\u2010specific proliferation and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>10\u2010 and <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u03b2\u2010dependent Treg function were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Preventive application of <jats:styled-content style=\"fixed-case\">SLIT<\/jats:styled-content> in young children was safe (no relevant side effects in 21,170 single applications). After 12 and 24\u00a0months of treatment, the rate of allergen\u2010specific sensitization (specific IgE and <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> reactivity) was comparable in the treatment and the placebo group. However, verum\u2010treated patients displayed a significant up\u2010regulation of allergen\u2010specific IgG (p\u00a0&lt;\u00a00.05). Furthermore, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>10\u2010dependent inhibition (p\u00a0&lt;\u00a00.05) was observed <jats:italic>in vitro<\/jats:italic> in the treatment group but not in the placebo group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preventive <jats:styled-content style=\"fixed-case\">SLIT<\/jats:styled-content> is safe in children 2\u20135\u00a0yr of age and induces regulatory mechanisms involving allergen\u2010specific IgG and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>10. Based on this pilot study, large\u2010scale trials will need to investigate the modulation of sensitization and clinically relevant allergy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12310","type":"journal-article","created":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T06:05:34Z","timestamp":1416377134000},"page":"788-795","source":"Crossref","is-referenced-by-count":58,"title":["Preventive sublingual immunotherapy in preschool children: First evidence for safety and pro\u2010tolerogenic effects"],"prefix":"10.1111","volume":"25","author":[{"given":"Zsolt","family":"Sz\u00e9pfalusi","sequence":"first","affiliation":[{"name":"Department of Paediatrics Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Bannert","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Medical University of Vienna Vienna 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