{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:21:05Z","timestamp":1773098465594,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,3,21]],"date-time":"2015-03-21T00:00:00Z","timestamp":1426896000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Horse antithymocyte globulin (h\u2010<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\">ATGAM<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup>) is the first choice of treatment in very severe patients with aplastic anemia who do not have any <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> matched sibling donor. h\u2010<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content> is a heterologous serum that may cause anaphylaxis. Alternative treatment strategies must be planned in case of hypersensitivity. Desensitization must be considered in patients without an alternative treatment of choice. We aimed to present the h\u2010<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content> desensitization protocol and consider its effectiveness in patients with aplastic anemia who are hypersensitized with h\u2010<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content> and do not have an alternative treatment of choice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Skin prick tests were performed with non\u2010diluted solution in eight very severe patients with aplastic anemia who are followed up in Ege University Children's Hospital. Although skin prick test was found negative in these eight patients, different dilution h\u2010<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content> intradermal tests were performed and found positive in all patients. h\u2010<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content> desensitization program was started to these hypersensitized patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Desensitization program was started to six male and two female very severe patients with aplastic anemia whose ages were between seven and 19\u00a0yr (median: 12.9\u00a0yr). All of the patients completed the desensitization program. While local reaction was seen in two patients, systemic reaction was seen in one patient and late reaction was seen in one patient during and after desensitization program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A successful desensitization program with h\u2010<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content> in children with aplastic anemia is presented. Even though there is not an exposure before to such high allergy potential heterologous serum, skin tests should be performed and desensitization must be started to patients who are hypersensitized to h\u2010<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>. As the expected effectiveness of the treatment is so much, the desensitization protocol can be carried out safely and effectively with trained stuff although allergic reactions can be seen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12335","type":"journal-article","created":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T10:39:04Z","timestamp":1421836744000},"page":"168-172","source":"Crossref","is-referenced-by-count":8,"title":["A successful desensitization protocol for horse\u2010derived antithymocyte globulin in severe aplastic anemia"],"prefix":"10.1111","volume":"26","author":[{"given":"Esen","family":"Demir","sequence":"first","affiliation":[{"name":"Department of Pediatric Allergy Children's Hospital Ege University Faculty of Medicine Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4059-829X","authenticated-orcid":false,"given":"Nur\u015fen","family":"Cigerci 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