{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:19:52Z","timestamp":1791328792442,"version":"4.3.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,3,21]],"date-time":"2015-03-21T00:00:00Z","timestamp":1426896000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Preeclampsia is a possible risk factor for childhood asthma in the offspring. Our aim was to find whether preeclampsia is associated with childhood asthma. We also aimed to study whether a possible association can be explained by factors shared by siblings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All eligible live singletons born in Denmark during 1993\u20132007 were identified (N\u00a0=\u00a0923,533), and the occurrence of preeclampsia during the index pregnancy was determined. The children were followed from their 3rd birthday to the first hospitalization, outpatient contact or prescription for asthma, emigration, death, their 18th birthday, or the end of 2010, whichever came first. We carried out a nested case\u2010control and a case\u2010sibling study with density sampling to estimate incidence rate ratio (<jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content>) of asthma as a function of maternal preeclampsia, using conditional logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 115,522 asthma cases were identified during 1996\u20132010. In the case\u2010control analysis, the overall <jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content> of asthma for those exposed to maternal preeclampsia was 1.19 (95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 1.15, 1.24). The <jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content>s for asthma according to early and late onset preeclampsia were 1.88 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.67, 2.11) and 1.14 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.10, 1.19). In the case\u2010sibling analysis, the corresponding <jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content>s were 1.06 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.98, 1.14), 1.15 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.02, 1.29), and 1.02 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.93, 1.11), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early onset preeclampsia was associated with an increased risk of asthma in the offspring, but part of this association may be due to confounding by factors shared by siblings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12344","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T15:54:48Z","timestamp":1422633288000},"page":"181-185","source":"Crossref","is-referenced-by-count":35,"title":["Maternal preeclampsia and childhood asthma in the offspring"],"prefix":"10.1111","volume":"26","author":[{"given":"Xiaoqin","family":"Liu","sequence":"first","affiliation":[{"name":"Section for Epidemiology Department of Public Health Aarhus University Aarhus Denmark"},{"name":"Department of Epidemiology and Social Science on Reproductive Health Shanghai Institute of Planned Parenthood Research WHO Collaborating Center for Research in Human Reproduction National Population &amp; Family Planning Key Laboratory of Contraceptive Drugs and Devices Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rn","family":"Olsen","sequence":"additional","affiliation":[{"name":"Section for Epidemiology Department of Public Health Aarhus University Aarhus Denmark"},{"name":"Department of Epidemiology Fielding School of Public Health University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esben","family":"Agerbo","sequence":"additional","affiliation":[{"name":"National Centre for Register\u2010Based Research Aarhus University Aarhus Denmark"},{"name":"CIRRAU\u2010Centre for Integrated Register\u2010based Research Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Social Science on Reproductive Health Shanghai Institute of Planned Parenthood Research WHO Collaborating Center for Research in Human Reproduction National Population &amp; Family Planning Key Laboratory of Contraceptive Drugs and Devices Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Sen","family":"Wu","sequence":"additional","affiliation":[{"name":"Section for Epidemiology Department of Public Health Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Li","sequence":"additional","affiliation":[{"name":"Section for Epidemiology Department of Public Health Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.070169"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsp121"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1746-1561.2006.00062.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027202"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.94.1.136"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181fdfb11"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.02.010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2255"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.107607"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.110558"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200512-1978OC"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.06.060"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-14-101"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.117358"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.08.019"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2010.509931"},{"key":"e_1_2_7_18_1","first-page":"263","article-title":"The Danish National Hospital Register. 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