{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:40:21Z","timestamp":1769838021258,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T00:00:00Z","timestamp":1429747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Leti Pharma GmbH, Germany"},{"name":"Novartis\/Leti, Germany\/Spain"},{"name":"Glaxo-Smith-Kline, UK\/Germany"},{"name":"Essex-Pharma, Germany"},{"name":"Cytos, Switzerland"},{"name":"Curalogic, Denmark"},{"name":"Roxall, Germany"},{"name":"Biomay Austria"},{"name":"Thermo-Fisher, Germany"},{"name":"MEDA-Pharma GmbH, Germany"},{"name":"ALK-Abello, Denmark"},{"name":"Allergopharma, Germany"},{"name":"Stallergenes, France"},{"name":"HAL, The Netherlands"},{"name":"Artu Biologicals, The Netherlands"},{"name":"Allergy-Therapeutics\/Bencard, UK\/Germany"},{"name":"Hartington, Spain"},{"name":"Lofarma, Italy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Allergen immunotherapy (<jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content>) is effective treatment for allergic diseases, and subcutaneous use of depigmented polymerized extracts may allow rapid up\u2010dosing and safe therapy. To date, there is little information on their safety and clinical effects for children and adolescents with allergic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective survey of patient notes of 2927 children and adolescents across 136 centres who had received subcutaneous AIT (SCIT) with depigmented polymerized extracts to pollen or mite allergens for at least 1\u00a0yr to collect documentation on safety and clinical symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>16.3% percent of patients had local reactions, of these 148 were larger than 12\u00a0cm in diameter. Systemic reactions were documented in 1.6% of children and in 0.8% of adolescents. There were no documented cases of anaphylactic shock. There were significant reductions in the frequency of patients with recorded nasal symptoms over time of treatment. Moreover, the prescribing rate of rescue medication was reduced over the course of <jats:styled-content style=\"fixed-case\">SCIT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These \u2018real\u2010life\u2019 data from a large retrospective analysis including 2927 children and adolescents with pollen\u2010 and\/or mite\u2010induced allergic rhinoconjunctivitis with\/or without allergic asthma indicate that <jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content> with depigmented polymerized extracts is well tolerated, and they are compatible with clinical response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12347","type":"journal-article","created":{"date-parts":[[2015,1,31]],"date-time":"2015-01-31T05:17:48Z","timestamp":1422681468000},"page":"280-286","source":"Crossref","is-referenced-by-count":15,"title":["Safety and effect on reported symptoms of depigmented polymerized allergen immunotherapy: a retrospective study of 2927 paediatric patients"],"prefix":"10.1111","volume":"26","author":[{"given":"Oliver","family":"Pfaar","sequence":"first","affiliation":[{"name":"Center for Rhinology and Allergology Wiesbaden Germany"},{"name":"Department of Otorhinolaryngology Head and Neck Surgery Universit\u00e4tsmedizin Mannheim Medical Faculty Mannheim Heidelberg University Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"Sager","sequence":"additional","affiliation":[{"name":"LETI Pharma Witten Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas S.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Leukocyte Biology Section National Heart and Lung Institute Imperial College London London UK"},{"name":"Department of Allergy Royal National Throat Nose and Ear Hospital University College London Hospital NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70271-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)78276-6"},{"issue":"1","key":"e_1_2_8_5_1","first-page":"CD001936","article-title":"Allergen injection immunotherapy for seasonal allergic rhinitis","author":"Calderon MA","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.01.049"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2012.01313.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40629-014-0032-2"},{"key":"e_1_2_8_10_1","first-page":"455","article-title":"Adverse effects and fatalities associated with subcutaneous allergen immunotherapy","volume":"21","author":"Bukantz SC","year":"2008","journal-title":"Clin Allergy Immunol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000230518","article-title":"Preparation and properties of, allergoids, derived from native pollen allergens by mild formalin treatment","volume":"41","author":"Marsh DG","year":"1971","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(85)90661-X"},{"key":"e_1_2_8_13_1","first-page":"30","article-title":"Skin tests with native, depigmented and glutaraldehyde polymerized allergen extracts","volume":"15","author":"Casanovas M","year":"2005","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000110888"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2010.31.3334"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03521.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02413.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02736.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12219"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02667.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3437"},{"key":"e_1_2_8_22_1","first-page":"58","article-title":"Safety of ultrashort\u2010term sit with pollen allergoids adjuvanted by monophosphoryl lipid A: a prospective Italian survey","volume":"43","author":"Crivellaro M","year":"2011","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12383"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.11.019"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.12347","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.12347","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.12347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:42:48Z","timestamp":1696225368000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.12347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,23]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/pai.12347"],"URL":"https:\/\/doi.org\/10.1111\/pai.12347","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,23]]}}}