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Multiple s\u2010IgE analyses may provide insight into this relationship, thus a microarray chip was developed within the <jats:styled-content style=\"fixed-case\">EU<\/jats:styled-content>\u2010funded Me<jats:styled-content style=\"fixed-case\">DALL<\/jats:styled-content> project. The main objective was to evaluate the performance of the Me<jats:styled-content style=\"fixed-case\">DALL<\/jats:styled-content>\u2010chip compared to Immuno<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> and skin prick test (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>) in detecting allergic sensitization in children and secondarily to investigate the association to asthma and allergic rhinitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From the \u2018Environment and Childhood Asthma Study\u2019, 265 children were investigated at 10 and 16\u00a0yr of age with clinical examination, interview, <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>, Immuno<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>, and the Me<jats:styled-content style=\"fixed-case\">DALL<\/jats:styled-content>\u2010chip including 152 allergen components in the analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Allergic sensitization at 10\u00a0yr was more frequently detected using the Me<jats:styled-content style=\"fixed-case\">DALL<\/jats:styled-content>\u2010chip (38.1%) compared to the Immuno<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> (32.8%) (p\u00a0=\u00a00.034) and <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> (25.5%) (p\u00a0&lt;\u00a00.001), but no significant difference was seen at 16\u00a0yr (Me<jats:styled-content style=\"fixed-case\">DALL<\/jats:styled-content>\u2010chip 49.8%, Immuno<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> 48.6%, <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> 45.8%). The Me<jats:styled-content style=\"fixed-case\">DALL<\/jats:styled-content>\u2010chip did not differ significantly from the Immuno<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> in terms of detecting allergic sensitization in subjects with rhinitis or asthma at 10 or 16\u00a0yr.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of allergic sensitization increased by all three diagnostic tests from 10 to 16\u00a0yr was similar by <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> and Immuno<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> and significantly higher with the Me<jats:styled-content style=\"fixed-case\">DALL<\/jats:styled-content>\u2010chip at 10\u00a0yr. All three tests were comparable for identification of allergic sensitization among children with current rhinitis or asthma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12366","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T06:07:15Z","timestamp":1425017235000},"page":"239-246","source":"Crossref","is-referenced-by-count":51,"title":["The use of the Me<scp>DALL<\/scp>\u2010chip to assess IgE sensitization: a new diagnostic tool for allergic disease?"],"prefix":"10.1111","volume":"26","author":[{"given":"Ingebj\u00f8rg","family":"Skrindo","sequence":"first","affiliation":[{"name":"Faculty of Medicine Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Lupinek","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Allergy Research Centre of Pathophysiology, Infectology and Immunology Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Valenta","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Allergy Research Centre of Pathophysiology, Infectology and Immunology Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vegard","family":"Hovland","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Institute of Clinical Medicine University of Oslo Oslo Norway"},{"name":"Department of Pediatrics Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Pahr","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Allergy Research Centre of Pathophysiology, Infectology and Immunology Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Baar","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Allergy Research Centre of Pathophysiology, Infectology and Immunology Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai\u2010H\u00e5kon","family":"Carlsen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Institute of Clinical Medicine University of Oslo Oslo Norway"},{"name":"Department of Pediatrics Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petter","family":"Mowinckel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Institute of Clinical Medicine University of Oslo Oslo Norway"},{"name":"Department of Pediatrics Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Wickman","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine Karolinska Institutet and Sachs' Children and Youth Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Melen","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine Karolinska Institutet and Sachs' Children and Youth Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Bousquet","sequence":"additional","affiliation":[{"name":"University Hospital Montpellier Montpellier France"},{"name":"MACVIA\u2010LR Fighting Chronic Diseases for Healthy Ageing R\u00e9gion Languedoc Roussillon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep M.","family":"Anto","sequence":"additional","affiliation":[{"name":"Centre for Research in Environmental Epidemiology (CREAL) IMIM (Hospital del Mar Medical Research Institute) Departament de Ci\u00e8ncies Experimentals i de la Salut Universitat Pompeu Fabra CIBER Epidemiolog\u00eca y Salud P\u00f9blica Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin C.","family":"L\u00f8drup Carlsen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Institute of Clinical Medicine University of Oslo Oslo Norway"},{"name":"Department of Pediatrics Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,23]]},"reference":[{"issue":"14","key":"e_1_2_9_2_1","first-page":"48s","article-title":"A. 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