{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:31:08Z","timestamp":1781879468915,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T00:00:00Z","timestamp":1429747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Cow's milk allergy (CMA<\/jats:styled-content>) is the most common food allergy in infancy. Food allergy is generally triggered through ingestion, but can also be triggered through skin contact. We investigated the incidence and the clinical significance of cow's milk protein (CMP<\/jats:styled-content>)\u2010induced contact urticaria in individuals with CMA<\/jats:styled-content> with and without atopic dermatitis (AD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 157 children of whom 133 were diagnosed with CMA<\/jats:styled-content> were participated. The study was based on observational data gathered in the course of patient care, including a skin prick test and a \u2018finger test\u2019, in which cow's milk is applied on the cheek by a physician's finger to detect contact urticaria.<\/jats:p><\/jats:sec>Results<\/jats:title>Eighty nine of 133 patients (66.9%) had IgE\u2010mediated CMA<\/jats:styled-content>. Forty of these 89 (44.9%) tested positive in the finger test. Family atopy was higher in those with positive contact urticaria [21\/40 (52.5%) vs. 14\/49 (28.5%), p\u00a0=\u00a00.029]. Patients with positive vs. negative CMP<\/jats:styled-content> contact urticaria had higher incidence of multiple food allergies [20 of 40 (50%) vs. 7\/49 (14.3%), p\u00a0<\u00a00.004]. IgE\u2010mediated CMA<\/jats:styled-content> patients with AD<\/jats:styled-content> had statistically higher CMP<\/jats:styled-content> allergic contact urticaria compared to patients without AD<\/jats:styled-content> [71% (15\/21) vs. 37% (25\/68), p\u00a0=\u00a00.0064]. Children with non\u2010IgE milk allergy and healthy control group did not have contact urticaria to CMP<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>CMP<\/jats:styled-content> contact urticaria exists only in patients with IgE\u2010mediated CMA<\/jats:styled-content>. A \u2018finger test\u2019 to CMP<\/jats:styled-content> should be part of the evaluation of CMA<\/jats:styled-content> patients, and positivity suggests the potential for multiple food allergies, especially to sesame and egg.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12375","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T01:08:42Z","timestamp":1426554522000},"page":"218-222","source":"Crossref","is-referenced-by-count":16,"title":["The significance of allergic contact urticaria to milk in children with cow's milk allergy"],"prefix":"10.1111","volume":"26","author":[{"given":"Vered","family":"Schichter\u2010Konfino","sequence":"first","affiliation":[{"name":"Division of Allergy & Clinical Immunology Bnai\u2010Zion Medical Center Rappaport Faculty of Medicine Technion Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meital","family":"Almog","sequence":"additional","affiliation":[{"name":"Division of Allergy & Clinical Immunology Bnai\u2010Zion Medical Center Rappaport Faculty of Medicine Technion Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Bamberger","sequence":"additional","affiliation":[{"name":"Pediatric Department Bnai\u2010Zion Medical Center Rappaport Faculty of Medicine Technion Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drora","family":"Berkowitz","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Bnai\u2010Zion Medical Center Rappaport Faculty of Medicine Technion Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aharon","family":"Kessel","sequence":"additional","affiliation":[{"name":"Division of Allergy & Clinical Immunology Bnai\u2010Zion Medical Center Rappaport Faculty of Medicine Technion Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.11.020"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.020"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2007.00562.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.02.036"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62908-0"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1994.tb02026.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.2340\/0001555566438442","article-title":"Milk causes a rapid urticarial reaction on the skin of children with atopic dermatitis and milk allergy","volume":"66","author":"Salo OP","year":"1986","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_9_1","first-page":"271","article-title":"Skin tests for immediate, type I allergic reactions","volume":"65","author":"Pepys J","year":"1972","journal-title":"Proc R Soc Med"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)70099-9"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.09.032"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12309"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.03.045"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1998.tb04983.x"},{"key":"e_1_2_5_15_1","first-page":"168","article-title":"Severe systemic allergic reaction induced by accidental skin contact with cow milk in a 16\u2010year\u2010old boy. 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