{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:14:26Z","timestamp":1791274466282,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,24]],"date-time":"2015-05-24T00:00:00Z","timestamp":1432425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Mothers and Children's Environmental Health Project of the Ministry of Environment, Republic of Korea"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Exposure to indoor air pollutants is thought to cause allergic inflammation. Volatile organic compounds (<jats:styled-content style=\"fixed-case\">VOC<\/jats:styled-content>s) are one of the aggravating factors of asthma and other allergic diseases. However, the influence of <jats:styled-content style=\"fixed-case\">VOC<\/jats:styled-content>s on development of atopic dermatitis is ambiguous in the clinical field. We therefore investigated the associations of indoor total volatile organic compounds (<jats:styled-content style=\"fixed-case\">TVOC<\/jats:styled-content>s) and development of atopic dermatitis in young Korean children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From the birth cohort of a <jats:styled-content style=\"fixed-case\">MO<\/jats:styled-content>thers and Children's Environmental Health (<jats:styled-content style=\"fixed-case\">MOCEH<\/jats:styled-content>) study, 257 infants, whose parents agreed with the environmental measurement, were enrolled. Total <jats:styled-content style=\"fixed-case\">VOC<\/jats:styled-content>s were measured in infant's bedrooms at the age of 6\u00a0month. A total of 105 parents answered a questionnaire at 36\u00a0month. Concentrations of <jats:styled-content style=\"fixed-case\">TVOC<\/jats:styled-content>s were divided into two groups by third quartile (75th). Associations between the high <jats:styled-content style=\"fixed-case\">VOC<\/jats:styled-content>s exposure group and development of atopic dermatitis at the age of 36\u00a0months were estimated by multivariate logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average concentration of <jats:styled-content style=\"fixed-case\">TVOC<\/jats:styled-content>s was 174.7\u00a0\u00b1\u00a0115.1\u00a0\u338d\/m<jats:sup>3<\/jats:sup>. We defined the high <jats:styled-content style=\"fixed-case\">TVOC<\/jats:styled-content>s exposure group by those with more than 75 percentile of the distribution (242.1\u00a0\u338d\/m<jats:sup>3<\/jats:sup>). An increased risk of atopic dermatitis was observed in the high <jats:styled-content style=\"fixed-case\">TVOC<\/jats:styled-content>s exposure group, after adjustment for parents history of allergy, household income, breast\u2010feeding longer than 6\u00a0month (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a03.116, 95% Cl 1.041\u20139.323). Risk of atopic dermatitis was increased when the family bought new furniture within 1\u00a0yr.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results showed that exposure to high concentration of <jats:styled-content style=\"fixed-case\">VOC<\/jats:styled-content>s during infancy, an indoor pollutant, increased the risk of atopic dermatitis at 36\u00a0months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12393","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T17:05:49Z","timestamp":1428944749000},"page":"352-358","source":"Crossref","is-referenced-by-count":35,"title":["Indoor total volatile organic compounds exposure at 6\u00a0months followed by atopic dermatitis at 3 years in children"],"prefix":"10.1111","volume":"26","author":[{"given":"Jung Hyun","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Pediatrics School of Medicine Ewha Womans University Seoul 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