{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:32:12Z","timestamp":1790814732987,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"German Federal Ministry of Education and Research BMBF","award":["07015633"],"award-info":[{"award-number":["07015633"]}]},{"name":"German Federal Ministry of Education and Research BMBF","award":["07 ALE 27"],"award-info":[{"award-number":["07 ALE 27"]}]},{"name":"German Federal Ministry of Education and Research BMBF","award":["01EE9405\/5"],"award-info":[{"award-number":["01EE9405\/5"]}]},{"name":"German Federal Ministry of Education and Research BMBF","award":["01EE9406"],"award-info":[{"award-number":["01EE9406"]}]},{"name":"German Research Foundation DFG","award":["KE 1462\/2-1"],"award-info":[{"award-number":["KE 1462\/2-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In adults, subjects sensitized to <jats:italic>Staphylococcus aureus<\/jats:italic> enterotoxins (SE) seem to have an increased risk of asthma, whereas this association is less clear in childhood and adolescence. The primary aim of the present analysis was to examine the association between sensitization to SE and asthma at the age of 20\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The German Multicentre Allergy Study recruited 1314 healthy newborns in 1990. We analyzed data from 61 asthmatics (based on at least two criteria: physician diagnosed asthma ever, wheezing in the last 12\u00a0months, asthma medication in the last 12\u00a0months) and 122 healthy study participants at age 20. In serum, specific Immunoglobulin E (IgE) to SE and common aeroallergens were measured. The association between asthma at age 20 and sensitization to SE was estimated by logistic regression models considering allergic, socio\u2010demographic, and lifestyle factors as potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010five percent of the included participants were female. At age 20, subjects sensitized to SE were more likely to have asthma than not\u2010sensitized subjects: raw odds ratio (OR) 2.5, 95%\u2010confidence interval (95%CI) [1.3\u20104.7]; adjusted OR 1.6, 95%CI [0.8\u20103.4].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Asthmatics at age 20 were more often sensitized to SE compared to controls. Our study may indicate a moderate relationship between SE\u2010sensitization and asthma; however, this association attenuated after adjusting for potential confounders and was no longer statistically significant. Longitudinal investigations with SE\u2010IgE measurements at different time points in larger samples are needed to explore the temporal manner of this relationship.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12396","type":"journal-article","created":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T06:06:49Z","timestamp":1430806009000},"page":"461-465","source":"Crossref","is-referenced-by-count":7,"title":["Is immunoglobulin E to <i>Staphylococcus aureus<\/i> enterotoxins associated with asthma at 20\u00a0years?"],"prefix":"10.1111","volume":"26","author":[{"given":"Ina","family":"Sintobin","sequence":"first","affiliation":[{"name":"Upper Airways Research Laboratory Department of Otorhinolaryngology and Head and Neck Surgery Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Keil","sequence":"additional","affiliation":[{"name":"Institute for Social Medicine, Epidemiology and Health Economics Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"},{"name":"Institute of Clinical Epidemiology and Biometry University W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pneumology and Immunology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linus","family":"Grabenhenrich","sequence":"additional","affiliation":[{"name":"Institute for Social Medicine, Epidemiology and Health Economics Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Holtappels","sequence":"additional","affiliation":[{"name":"Upper Airways Research Laboratory Department of Otorhinolaryngology and Head and Neck Surgery Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Reich","sequence":"additional","affiliation":[{"name":"Institute for Social Medicine, Epidemiology and Health Economics Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Wahn","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pneumology and Immunology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Bachert","sequence":"additional","affiliation":[{"name":"Upper Airways Research Laboratory Department of Otorhinolaryngology and Head and Neck Surgery Ghent University Ghent Belgium"},{"name":"Division of Ear, Nose, and Throat Diseases Clintec Karolinska Institutet Stockholm 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