{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:46:14Z","timestamp":1790520374578,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T00:00:00Z","timestamp":1433462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Contact sensitization in children is more frequent than previously thought.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">ESSCA<\/jats:styled-content> collected patch test data from 11 European countries aggregated to 4 European regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six thousand and eight patients aged 1\u201316\u00a0years old with suspected allergic contact dermatitis were analyzed during a period of 8\u00a0years (2002\u20132010). The overall prevalence of at least one positive reaction to a hapten was 36.9%. The 10 most frequent haptens were as follows: nickel sulfate, cobalt chloride and potassium dichromate, neomycin sulfate, <jats:italic>Myroxylon pereirae<\/jats:italic> resin (balsam of Peru), para\u2010phenylenediamine, chloromethylisothiazolinone\/methylisothiazolinone 3:1, fragrance mix, lanolin alcohols, and colophony. No difference was found in the prevalence of at least one positive reaction to at least one hapten between boys and girls and between children with atopic dermatitis and children without. Children without atopic dermatitis, when compared with those with, had a significantly higher prevalence of contact sensitization for nickel sulfate (20.91% vs 16.87%, respectively), 4\u2010tert. butylphenol formaldehyde resin (1.61% vs. 0.7%), and para\u2010phenylenediamine (2.49% vs. 1.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations of the study<\/jats:title><jats:p>Chamber loading is not an exact science and variation may occur between staff and departments. Interinstitution variations in readings can occur. A possible geographic confounder is that the southern regions tested more children in the younger age group. Relevance was not addressed due to difficulties in the application of a set of uniform definitions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study adds information on the most common contact allergens detected in children which could help to define a Standard European <jats:italic>Pediatric<\/jats:italic> Baseline Series.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12397","type":"journal-article","created":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T06:23:04Z","timestamp":1430806984000},"page":"446-455","source":"Crossref","is-referenced-by-count":92,"title":["Patch test results in children and adolescents across Europe. Analysis of the <scp>ESSCA<\/scp> Network 2002\u20132010"],"prefix":"10.1111","volume":"26","author":[{"given":"Anna","family":"Belloni Fortina","sequence":"first","affiliation":[{"name":"Pediatric Dermatology Unit Department of Medicine University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Dermatology Churchill Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radoslaw","family":"Spiewak","sequence":"additional","affiliation":[{"name":"Department of Experimental Dermatology and Cosmetology Faculty of Pharmacy Jagiellonian University Medical College Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Fontana","sequence":"additional","affiliation":[{"name":"Pediatric Dermatology Unit Department of Medicine University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Schnuch","sequence":"additional","affiliation":[{"name":"Information Network of Departments of Dermatology (IVDK) University Medicine G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Uter","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Biometry and Epidemiology University of Erlangen\/N\u00fcrnberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01963.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12129"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000083"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01572.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02070.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2003.0225n.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-03827-3_24"},{"issue":"92","key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2340\/00015555924447","article-title":"Diagnostic features of atopic dermatitis","volume":"60","author":"Hanifin JM","year":"1980","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_10_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Development Core Team","year":"2014"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00406.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12027"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e318273a3e0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.07.030"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12043"},{"key":"e_1_2_7_16_1","first-page":"39","article-title":"Frequency of contact allergens in pediatric patients with atopic dermatitis","volume":"4","author":"Herro EM","year":"2011","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01852.x"},{"key":"e_1_2_7_18_1","unstructured":"Anonymous.Commission regulation (EC) No 552\/2009 of 22 June 2009 amending Regulation (EC) No 1907\/2006 of the European Parliament and of the Council on the Registration Evaluation Authorisation and Restriction of Chemicals (REACH) as regards Annex XVII.Official Journal L.2009."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01865.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01841.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.0309u.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03909.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2003.05491.x"},{"key":"e_1_2_7_24_1","first-page":"11","article-title":"Influence of environment exposures on the frequency of contact allergies in children and adolescents","volume":"19","author":"Czarnobilska E","year":"2012","journal-title":"Ann Agric Environ Med"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02863.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12117"},{"key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1610-0387.2011.07756.x","article-title":"Severe allergic reactions to para\u2010phenylenediamine in children and adolescents: should the patch\u00a0test concentration of PPD be changed?","volume":"10","author":"Spornraft\u2010Ragaller P","year":"2012","journal-title":"J\u00a0Dtsch Dermatol Ges"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06588.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08644.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01427.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/cod.12150","article-title":"Recommendation to include methylisothiazolinone in the European baseline patch test series\u2013on behalf of the\u00a0European Society of Contact Dermatitis and the European Environmental and Contact Dermatitis Research Group","volume":"69","author":"Bruze M","year":"2013","journal-title":"Contact Dermatitis"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12149"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12229"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10852.x"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.12397","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.12397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T08:24:42Z","timestamp":1696235082000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.12397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,5]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/pai.12397"],"URL":"https:\/\/doi.org\/10.1111\/pai.12397","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,5]]}}}