{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:33:55Z","timestamp":1792794835594,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KE 1462\/2-1"],"award-info":[{"award-number":["KE 1462\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The occurrence of allergic multimorbidity (coexistence of asthma, allergic rhinitis and eczema) has not been evaluated longitudinally from early childhood up to adulthood in a population\u2010based study sample. We aimed to determine the prevalence of allergic multimorbidity up to age 20 stratified by parental allergies and sex\/gender using extensive prospective follow\u2010up data from two decades of a birth cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In 1990, we recruited 1314 healthy newborns from 6 maternity wards across Germany for the population\u2010based\n                      <jats:styled-content style=\"fixed-case\">MAS<\/jats:styled-content>\n                      birth cohort study. The sample was purposely risk\u2010enriched by increasing the proportion of children at high allergy risk (i.e. at least 2 allergic family members among parents and siblings) from 19% in the source population to 38% in the final sample. The remaining 62% of all\n                      <jats:styled-content style=\"fixed-case\">MAS<\/jats:styled-content>\n                      children had a low or no allergy risk. Symptoms, medication and doctor's diagnoses of allergic diseases have been assessed using standardized questionnaires including validated\n                      <jats:styled-content style=\"fixed-case\">ISAAC<\/jats:styled-content>\n                      questions in 19 follow\u2010up assessments up to age 20. Allergic multimorbidity at each time point was defined as the coexistence of at least 2 of the following diseases in one participant: asthma, allergic rhinitis and eczema.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Response at age 20 was 72% (n\u00a0=\u00a0942) of all recruited participants. At age 20, 18.5% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 15.0\u201322.5%) of all participants with allergic parents had 2 or 3 concurrent allergies as compared to only 6.3% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 4.3\u20139.0%) of those with non\u2010allergic parents. At this age, allergic multimorbidity was similar in women and men (12.7% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 9.7\u201316.2%) vs. 11.6% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 8.9\u201314.8%)), whereas single allergic diseases were slightly more common in women than men (24.2% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 20.2\u201328.5%) vs. 20.1% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 16.6\u201324.0%)). Asthma occurred more frequently with coexisting allergic rhinitis and\/or eczema than as a single entity from pre\u2010puberty to adulthood.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Having parents with allergies is not only a strong predictor to develop any allergy, but it strongly increases the risk of developing allergic multimorbidity. In males and females alike, coexisting allergies were increasingly common throughout adolescence up to adulthood. Particularly asthma occurred in both sexes more frequently with coexisting allergies than as a single entity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.12410","type":"journal-article","created":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T08:24:43Z","timestamp":1432283083000},"page":"431-437","source":"Crossref","is-referenced-by-count":162,"title":["Allergic multimorbidity of asthma, rhinitis and eczema over 20\u00a0years in the German birth cohort\n                    <scp>MAS<\/scp>"],"prefix":"10.1111","volume":"26","author":[{"given":"Hannah","family":"Gough","sequence":"first","affiliation":[{"name":"Institute of Social Medicine Epidemiology and Health Economics Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linus","family":"Grabenhenrich","sequence":"additional","affiliation":[{"name":"Institute of Social Medicine Epidemiology and Health Economics Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Reich","sequence":"additional","affiliation":[{"name":"Institute of Social Medicine Epidemiology and Health Economics Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Eckers","sequence":"additional","affiliation":[{"name":"Institute of Social Medicine Epidemiology and Health Economics Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Nitsche","sequence":"additional","affiliation":[{"name":"Centre for Paediatric and Adolescent Medicine University Medical Centre Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Schramm","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Medical Centre D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Beschorner","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Westmecklenburg Hospital Hagenow Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Schuster","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Medical Centre D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl\u2010Peter","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Forster","sequence":"additional","affiliation":[{"name":"Department of Paediatrics St. Josefs Hospital Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Zepp","sequence":"additional","affiliation":[{"name":"Centre for Paediatric and Adolescent Medicine University Medical Centre Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Ae","family":"Lee","sequence":"additional","affiliation":[{"name":"Max\u2010Delbr\u00fcck\u2010Centre for Molecular Medicine Berlin\u2010Buch Germany"},{"name":"Experimental and Clinical Research Centre Charit\u00e9 Campus Buch Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate L.","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl E.","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Wahn","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Division of Pneumonology Immunology and Intensive Care Medicine incl. 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