{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:15Z","timestamp":1787015955731,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}],"id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Airway diseases are highly prevalent in infants and cause significant morbidity. We aimed to determine the incidence and risk factors for respiratory morbidity in a Spanish cohort of moderate\u2010to\u2010late preterm (\n                      <jats:styled-content style=\"fixed-case\">MLP<\/jats:styled-content>\n                      ) infants prospectively followed during their first year of life.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">SAREPREM<\/jats:styled-content>\n                      is a multicenter, prospective, longitudinal study. Preterm infants born at 32\u201335\u00a0weeks of gestation with no comorbidities were enrolled within 2\u00a0weeks of life and followed at 2\u20134\u00a0weeks, 6, and 12\u00a0months of age. Multivariate mixed\u2010models were performed to identify independent risk factors associated with (i) development of bronchiolitis, (ii) recurrent wheezing, or (iii) related hospital admissions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 977 preterm infants were included, and 766 (78.4%) completed follow\u2010up. Of those, 365 (47.7%) developed bronchiolitis during the first year, 144 (18.8%) recurrent wheezing, and 48 (6.3%) were hospitalized. While low birthweight, day care attendance (\n                      <jats:styled-content style=\"fixed-case\">DCA<\/jats:styled-content>\n                      ) and school\u2010age siblings were significantly and independently associated with both the development of bronchiolitis and recurrent wheezing, lower maternal age increased the risk for bronchiolitis and respiratory\u2010related hospitalizations. Lastly, mechanical ventilation was associated with a higher risk of bronchiolitis and history of asthma in any parent increased the likelihood of developing recurrent wheezing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In this study, several non\u2010modifiable parameters (family history of asthma, low birthweight, need for mechanical ventilation) and modifiable parameters (young maternal age,\n                      <jats:styled-content style=\"fixed-case\">DCA<\/jats:styled-content>\n                      , or exposure to school\u2010age siblings) were identified as significant risk factors for the development of bronchiolitis and recurrent wheezing during the first year of life in\n                      <jats:styled-content style=\"fixed-case\">MLP<\/jats:styled-content>\n                      infants.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.12414","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T14:28:11Z","timestamp":1432823291000},"page":"797-804","source":"Crossref","is-referenced-by-count":29,"title":["Risk factors for bronchiolitis, recurrent wheezing, and related hospitalization in preterm infants during the first year of life"],"prefix":"10.1111","volume":"26","author":[{"given":"Eduardo G.","family":"P\u00e9rez\u2010Yarza","sequence":"first","affiliation":[{"name":"Division of Pediatric Respiratory Medicine Hospital Universitario Donostia\u2010Instituto Biodonostia San Sebasti\u00e1n Spain"},{"name":"Biomedical Research Centre Network for Respiratory Diseases (CIBERES) San Sebasti\u00e1n Spain"},{"name":"Department of Pediatrics University of the Basque Country (UPV\/EHU) San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Moreno\u2010Gald\u00f3","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Unit Department of Pediatrics, Obstetrics, Gynecology and Preventive Medicine Hospital Universitario Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavio","family":"Ramilo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Pediatrics Nationwide Children's Hospital The Ohio State University Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Rub\u00ed","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Section Hospital Torrec\u00e1rdenas Almer\u00eda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amparo","family":"Escribano","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Unit Hospital Cl\u00ednico Universitario Universidad de Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hospital San Juan de la Cruz \u00dabeda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaia","family":"Sard\u00f3n","sequence":"additional","affiliation":[{"name":"Division of Pediatric Respiratory Medicine Hospital Universitario Donostia\u2010Instituto Biodonostia San Sebasti\u00e1n Spain"},{"name":"Department of Pediatrics University of the Basque Country (UPV\/EHU) San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Oliva","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Unit Hospital Universitario Nuestra Se\u00f1ora de la Candelaria Tenerife 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Cl\u00ednico Universitario Virgen de la Arrixaca Universidad de Murcia Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"P\u00e9rez\u2010Fr\u00edas","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Unit Hospital Materno\u2010Infantil M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valle","family":"Velasco","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Unit Hospital Cl\u00ednico Universitario Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Torres\u2010Borrego","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary and Allergy Unit Hospital Reina Sof\u00eda C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Figuerola","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Section Hospital Universitario Son Espases Palma de Mallorca 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