{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:58:14Z","timestamp":1791590294212,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T00:00:00Z","timestamp":1443398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Assessment of inflammation is becoming a common practice in the clinical work\u2010up of children with persistent asthma. Biomarkers of Th2\u2010mediated inflammation include blood eosinophils (B\u2010Eos), exhaled nitric oxide (FeNO), total serum IgE (S\u2010IgE), and serum periostin. The aim of this study was to investigate the associations between asthma morbidity and increased levels of these biomarkers in pediatric asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>School\u2010age children (n = 96) with various manifestations of persistent asthma were included in this nationwide Swedish study. The protocol included the asthma control test, Juniper's quality of life questionnaire (QoL), assessment of pulmonary function, bronchial hyperresponsiveness, height\u2010adjusted FeNO, blood sampling for S\u2010IgE, B\u2010Eos, and periostin, and high\u2010resolution computed tomography (HRCT) of the lungs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children with <jats:italic>both<\/jats:italic> high levels of height\u2010adjusted FeNO and B\u2010Eos were younger (p = 0.001), had more often severe asthma (p = 0.015), were more allergic (p &lt; 0.001), had a reduced asthma control (p = 0.035), reduced QoL (p = 0.035), more exacerbations (p = 0.004), reduced FEV1\/FVC (p = 0.001), and increased bronchial hyperresponsiveness (p &lt; 0.001) as well as greater bronchial wall thickening on HRCT (p = 0.022) compared to those with low levels of both biomarkers. Grouping children according to high and low serum periostin levels did not relate to differences in clinical characteristics and biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Assessment of <jats:italic>both<\/jats:italic> local and systemic Th2\u2010mediated inflammation by the analysis of easily attainable biomarkers such as exhaled NO and blood eosinophils has a high predictive value for the identification of children with the highest asthma morbidity. Adjusting FeNO values according to the individual child's height increases the clinical usefulness of this biomarker.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12457","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T12:49:01Z","timestamp":1439383741000},"page":"772-779","source":"Crossref","is-referenced-by-count":59,"title":["Predicting asthma morbidity in children using proposed markers of Th2\u2010type inflammation"],"prefix":"10.1111","volume":"26","author":[{"given":"Jon R.","family":"Konradsen","sequence":"first","affiliation":[{"name":"Astrid Lindgren Children's Hospital Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Women's and Children's Health Karolinska Institutet Stockholm Sweden"},{"name":"Centre for Allergy Research Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Skantz","sequence":"additional","affiliation":[{"name":"Astrid Lindgren Children's Hospital Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Women's and Children's Health Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Nordlund","sequence":"additional","affiliation":[{"name":"Astrid Lindgren Children's Hospital Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Women's and Children's Health Karolinska Institutet Stockholm Sweden"},{"name":"Centre for Allergy Research Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Lidegran","sequence":"additional","affiliation":[{"name":"Astrid Lindgren Children's Hospital Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"James","sequence":"additional","affiliation":[{"name":"Centre for Allergy Research Karolinska Institutet Stockholm Sweden"},{"name":"The National Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Ono","sequence":"additional","affiliation":[{"name":"Shino\u2010Test Co, Ltd. Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichiro","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Saga Medical School Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Izuhara","sequence":"additional","affiliation":[{"name":"Division of Medical Biochemistry Department of Biomolecular Sciences Saga Medical School Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven\u2010Erik","family":"Dahl\u00e9n","sequence":"additional","affiliation":[{"name":"Centre for Allergy Research Karolinska Institutet Stockholm Sweden"},{"name":"The National Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell","family":"Alving","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University Uppsala 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