{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:40:56Z","timestamp":1790761256756,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T00:00:00Z","timestamp":1449619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is limited information regarding the onset and sensitization patterns of pollen food syndrome (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>) in children. The aim was to explore this within children referred to a specialist allergy clinic at a London Tertiary Hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 54 patients with seasonal allergic rhinitis (<jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>) were enrolled in equal numbers in three age groups; 0\u20135, 6\u201310, 11\u201315 years. Families completed a questionnaire on rhinitis, food symptoms and quality of life. Children underwent skin prick testing (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>) to fresh fruits, nuts and a blood test for microarray analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical diagnosis of <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> was made in 26\/54 (48%), increasing with age (group 1 = 3 (17%), group 2 = 9 (50%), group 3 = 14 (78%) (p = 0.03)). Microarray demonstrates children aged 2.8 years sensitized to pan\u2010allergens and 4.5 years symptomatic to pan\u2010allergens. Peach, cherry, carrot and strawberry <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> had the highest sensitivity and <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> at 100%. The sensitivity of <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>10 molecules on microarray was 92%, <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> 62% and <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> 87%. Microarray confirmed 69% of allergens on clinical history compared to 61% by <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>. Microarray and <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> had a 19% false\u2010negative rate.<\/jats:p><jats:p>The quality\u2010of\u2010life data showed moderate impact across all domains, and patients with <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> were significantly more likely to have increased anxiety over time spent preparing food (p = 0.029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We demonstrate that <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content> occurs in children from 1.4 years and <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> from 4.5 years with a changing pattern of pan\u2010allergen sensitization. Microarray and <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> have moderate concordance in confirming allergens. <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> impacts negatively on quality of life and should be assessed in all paediatric allergy patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12504","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T08:02:45Z","timestamp":1446624165000},"page":"134-140","source":"Crossref","is-referenced-by-count":32,"title":["Pollen food syndrome amongst children with seasonal allergic rhinitis attending allergy clinic"],"prefix":"10.1111","volume":"27","author":[{"given":"Sian","family":"Ludman","sequence":"first","affiliation":[{"name":"Royal London Hospital Barts Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Jafari\u2010Mamaghani","sequence":"additional","affiliation":[{"name":"Immunodiagnostics Division Thermo Fisher Scientific Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Ebling","sequence":"additional","affiliation":[{"name":"Division of Asthma, Allergy and Lung Biology, Diagnostic Immunology King's College London Viapath London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam T.","family":"Fox","sequence":"additional","affiliation":[{"name":"Division of Asthma, Allergy and Lung Biology MRC &amp; Asthma UK Centre in Allergic Mechanisms of Asthma King's College London Guy's and St Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Lack","sequence":"additional","affiliation":[{"name":"Division of Asthma, Allergy and Lung Biology MRC &amp; Asthma UK Centre in Allergic Mechanisms of Asthma King's College London Guy's and St Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Du Toit","sequence":"additional","affiliation":[{"name":"Division of Asthma, Allergy and Lung Biology MRC &amp; Asthma UK Centre in Allergic Mechanisms of Asthma King's College London Guy's and St Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01393.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.09.036"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00090303"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2013.779238"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-8707(42)90070-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2009.11.007"},{"issue":"2","key":"e_1_2_7_8_1","first-page":"41","article-title":"Food allergy in pollen\u2010sensitive patients","volume":"61","author":"Dreborg S","year":"1988","journal-title":"Ann Allergy"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1982.tb02323.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2004.11.011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12136"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(03)02008-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01197.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030483"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03759.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2003.00072.x"},{"issue":"10","key":"e_1_2_7_17_1","first-page":"1","article-title":"Skin tests used in type I allergy testing Position paper. 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