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In contrast to most other paediatric diseases, there is no established cure: current management is based upon dietary avoidance and the provision of rescue medication in the event of accidental reactions, which are common. This strategy has significant limitations and impacts adversely on health\u2010related quality of life. In the last decade, research into disease\u2010modifying treatments for food allergy has emerged, predominantly for peanut, egg and cow's milk. Most studies have used the oral route (oral immunotherapy, OIT), in which increasing amounts of allergen are given over weeks\u2013months. OIT has proven effective to induce immune modulation and \u2018desensitization\u2019 \u2013 that is, an increase in the amount of food allergen that can be consumed, so long as regular (typically daily) doses are continued. However, its ability to induce permanent tolerance once ongoing exposure has stopped seems limited. Additionally, the short\u2010 and long\u2010term safety of OIT is often poorly reported, raising concerns about its implementation in routine practice. Most patients experience allergic reactions and, although generally mild, severe reactions have occurred. Long\u2010term adherence is unclear, which rises concerns given the low rates of long\u2010term tolerance induction. Current research focuses on improving current limitations, especially safety. Strategies include alternative routes (sublingual, epicutaneous), modified hypoallergenic products and adjuvants (anti\u2010IgE, pre\u2010\/probiotics). Biomarkers of safe\/successful OIT are also under investigation.<\/jats:p>","DOI":"10.1111\/pai.12510","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T09:07:18Z","timestamp":1448269638000},"page":"117-125","source":"Crossref","is-referenced-by-count":74,"title":["Improving the safety of oral immunotherapy for food allergy"],"prefix":"10.1111","volume":"27","author":[{"given":"Marta","family":"Vazquez\u2010Ortiz","sequence":"first","affiliation":[{"name":"Section of Paediatrics Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9862-5161","authenticated-orcid":false,"given":"Paul J.","family":"Turner","sequence":"additional","affiliation":[{"name":"Section of Paediatrics Imperial College London London UK"},{"name":"Discipline of Paediatrics and Child Health School of Medicine University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12429"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12423"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1210"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.10.021"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1939-4551-6-21"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.112129"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.05.008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.060"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.12.1041"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.08.023"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.09.040"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12211"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12203"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02342.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(02)90351-2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000225158.75521.ad"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckt010"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.12.1125"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d6180"},{"key":"e_1_2_7_21_1","unstructured":"Food Standards Agency (FSA).\u201cMay contain\u201d labelling\u2014the consumer's perspective.2002. 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