{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:42:18Z","timestamp":1780353738385,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T00:00:00Z","timestamp":1453334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Allergy has sharply increased in affluent Western countries in the last 30 years. N\u20103 long\u2010chain polyunsaturated fatty acids (n\u20103 LCPUFA<\/jats:styled-content>s) may protect the immune system against development of allergy.<\/jats:p><\/jats:sec>Methods<\/jats:title>We prospectively categorized illnesses by body system in a subset of 91 children from the Kansas City cohort of the DIAMOND<\/jats:styled-content> (DHA<\/jats:styled-content> Intake and Measurement of Neural Development) study who had yearly medical records through 4 years of age. As infants, they were fed either a control formula without LCPUFA<\/jats:styled-content> (n = 19) or one of three formulas with LCPUFA<\/jats:styled-content> from docosahexaenoic acid (DHA<\/jats:styled-content>) and arachidonic acid (ARA<\/jats:styled-content>) (n = 72).<\/jats:p><\/jats:sec>Results<\/jats:title>Allergic illnesses in the first year were lower in the combined LCPUFA<\/jats:styled-content> group compared to the control. LCPUFA<\/jats:styled-content>s significantly delayed time to first allergic illness (p = 0.04) and skin allergic illness (p = 0.03) and resulted in a trend to reduced wheeze\/asthma (p = 0.1). If the mother had no allergies, LCPUFA<\/jats:styled-content>s reduced the risk of any allergic diseases (HR<\/jats:styled-content> = 0.24, 95% CI<\/jats:styled-content> = 0.1, 0.56, p = 0.0.001) and skin allergic diseases (HR<\/jats:styled-content> = 0.35, 95% CI<\/jats:styled-content> = 0.13, 0.93, p = 0.04). In contrast, if the mother had allergies, LCPUFA<\/jats:styled-content>s reduced wheezing\/asthma (HR<\/jats:styled-content> = 0.26, 95% CI<\/jats:styled-content> = 0.07, 0.9, p = 0.02).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>LCPUFA<\/jats:styled-content> supplementation during infancy reduced the risk of skin and respiratory allergic diseases in childhood with effects influenced by maternal allergies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12515","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T20:18:43Z","timestamp":1448655523000},"page":"156-161","source":"Crossref","is-referenced-by-count":66,"title":["Formula with long\u2010chain polyunsaturated fatty acids reduces incidence of allergy in early childhood"],"prefix":"10.1111","volume":"27","author":[{"given":"Amanda M.","family":"Foiles","sequence":"first","affiliation":[{"name":"University of Kansas Medical Center Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth H.","family":"Kerling","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo A.","family":"Wick","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deolinda M. F.","family":"Scalabrin","sequence":"additional","affiliation":[{"name":"Mead Johnson Nutrition Evansville IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Colombo","sequence":"additional","affiliation":[{"name":"University of Kansas Lawrence KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Carlson","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2010.10.048"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.006643"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12003"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3182072229"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12453"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12233"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12111"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00.16586100"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114507791845"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181b99cd5"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511006878"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00040.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3104"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.04031.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.01.002"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-012-0304-1"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28557"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.140418"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01939.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2008.084921"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114509991541"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1081\/JAS-120018633"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02411.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1996.tb122010.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858406289801"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-14-168"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.08.030"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01096.x"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00367.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03072.x"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.12515","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.12515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:44:22Z","timestamp":1695480262000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.12515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,21]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/pai.12515"],"URL":"https:\/\/doi.org\/10.1111\/pai.12515","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,21]]}}}