{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:14:19Z","timestamp":1790766859399,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T00:00:00Z","timestamp":1453766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/SAU\u2010ESA\/100275\/2008"],"award-info":[{"award-number":["PTDC\/SAU\u2010ESA\/100275\/2008"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PEst\u2010OE\/MAT\/UI0006\/2014"],"award-info":[{"award-number":["PEst\u2010OE\/MAT\/UI0006\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Scarce information is available about the relationships between indoor air quality (IAQ<\/jats:styled-content>) at day care centers (DCC<\/jats:styled-content>), the estimated predisposition for asthma, and the actual wheezing susceptibility.<\/jats:p><\/jats:sec>Methods<\/jats:title>In the Phase II<\/jats:styled-content> of ENVIRH<\/jats:styled-content> study, 19 DCC<\/jats:styled-content> were recruited after cluster analysis. Children were evaluated firstly using the ISAAC<\/jats:styled-content> questionnaire and later by a follow\u2010up questionnaire about recent wheezing. A positive asthma predictive index (API<\/jats:styled-content>) was considered as predisposition for asthma. Every DCC<\/jats:styled-content> was audited for IAQ<\/jats:styled-content> and monitored for chemical and biologic contaminants.<\/jats:p><\/jats:sec>Results<\/jats:title>We included 1191 children, with a median age of 43 (P25<\/jats:sub>\u2013P75<\/jats:sub>: 25\u201358)\u00a0months. Considering the overall sample, in the first questionnaire, associations were found between CO<\/jats:styled-content>2<\/jats:sub> concentration (increments of 200\u00a0ppm) and diagnosis of asthma (OR<\/jats:styled-content>: 1.10; 95% CI<\/jats:styled-content>: 1.00\u20131.20). Each increment of 100\u00a0\u03bcg\/m3<\/jats:sup> of total volatile organic compounds (TVOC<\/jats:styled-content>) and 1\u00a0\u03bcg of Der p1\/g of dust were associated with wheezing in the previous 12\u00a0months (OR<\/jats:styled-content>: 1.06; 95% CI<\/jats:styled-content>: 1.01\u20131.11 and OR<\/jats:styled-content>: 1.06; 95% CI<\/jats:styled-content>: 0.99\u20131.12, respectively). In the follow\u2010up questionnaire, TVOC<\/jats:styled-content> were again associated with wheezing (OR<\/jats:styled-content>: 1.05; 95% CI<\/jats:styled-content>: 1.00\u20131.11). Children exposed to fungal concentration above the 75th percentile had also higher odds of wheezing at follow\u2010up. TVOC<\/jats:styled-content> were associated with wheezing in children with either negative or positive API<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>IAQ<\/jats:styled-content> in DCC<\/jats:styled-content> seems to be associated with wheezing, in children with and without predisposition for asthma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12521","type":"journal-article","created":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T21:46:02Z","timestamp":1449956762000},"page":"299-306","source":"Crossref","is-referenced-by-count":39,"title":["Effect of indoor air quality of day care centers in children with different predisposition for asthma"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4129-133X","authenticated-orcid":false,"given":"Pedro","family":"Carreiro\u2010Martins","sequence":"first","affiliation":[{"name":"CEDOC Respiratory Research Group Nova Medical School Campo dos M\u00e1rtires da P\u00e1tria Lisbon 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