{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:35:34Z","timestamp":1778895334210,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T00:00:00Z","timestamp":1453334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006544","name":"Ministry of Health, State of Israel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006544","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patient quality of life improves following successful completion of oral immunotherapy (<jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content>), but the process itself might have undesirable effects. We aimed to evaluate patient quality of life following <jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content> initial induction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Hebrew version of the Food Allergy Quality of Life Questionnaire\u2010Parental Form (<jats:styled-content style=\"fixed-case\">FAQLQ<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>) was validated and administered to the parents of children following the first week of <jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content> for food allergy (n\u00a0=\u00a0119). Patient demographics and clinical history as well as the course of initial induction week were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pre\u2010<jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content> severity of food allergy, defined as severity of reactions due to accidental exposure to the allergenic food (anaphylactic reactions, p\u00a0=\u00a00.017; epinephrine use, p\u00a0=\u00a00.049; emergency room referrals p\u00a0=\u00a00.003; and hospital admissions, p\u00a0=\u00a00.015) and a lower number of tolerated doses during initial induction, reflective of a lower maximal tolerated dose for the different allergens (p\u00a0=\u00a00.011) were associated with worse total <jats:styled-content style=\"fixed-case\">FAQLQ<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content> scores. The number of tolerated doses during induction and pre\u2010OIT emergency room referrals remained significantly associated with worse total score of the <jats:styled-content style=\"fixed-case\">FAQLQ<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content> on multivariate analysis (p\u00a0=\u00a00.016 and p\u00a0=\u00a00.005, respectively). The correlation between the number of tolerated doses and quality of life scores was moderate\u2013strong primarily in children aged 6\u201312\u00a0years (Total score, r\u00a0=\u00a0\u22120.41, p\u00a0=\u00a00.001; Emotional Impact r\u00a0=\u00a0\u22120.42, p\u00a0=\u00a00.001; Food Anxiety, r\u00a0=\u00a0\u22120.38, p\u00a0=\u00a00.002; Social and Dietary Limitations, r\u00a0=\u00a0\u22120.33, p\u00a0=\u00a00.009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pre\u2010<jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content> reaction severity affects quality of life in both preschool and school\u2010aged food\u2010allergic children. In contrast, a lower maximal tolerated dose during <jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content> induction is associated with worse indices of quality of life primarily in children aged 6\u201312\u00a0years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12528","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T05:14:40Z","timestamp":1450415680000},"page":"263-268","source":"Crossref","is-referenced-by-count":38,"title":["Patient quality of life following induction of oral immunotherapy for food allergy"],"prefix":"10.1111","volume":"27","author":[{"given":"Na'ama","family":"Epstein Rigbi","sequence":"first","affiliation":[{"name":"Department of Pediatrics Assaf Harofeh Medical Center Zerifin Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yitzhak","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Assaf Harofeh Medical Center Zerifin Israel"},{"name":"Sackler School of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Allergy and Immunology Institute Assaf Harofeh Medical Center Zerifin Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Institute Assaf Harofeh Medical Center Zerifin Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Levy","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Institute Assaf Harofeh Medical Center Zerifin Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liat","family":"Nachshon","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Institute Assaf Harofeh Medical Center Zerifin Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnon","family":"Elizur","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Assaf Harofeh Medical Center Zerifin Israel"},{"name":"Sackler School of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Allergy and Immunology Institute Assaf Harofeh Medical Center Zerifin Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01421.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.12.1125"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.024"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12211"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02342.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60908-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12794"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2003.00072.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2013.2376"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.10.001"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2011.11.004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-10-25"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62301-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2012.08.015"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02304.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.02978.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2014.06.016"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12442"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.030"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200435"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(89)90005-6"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03454.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2012.01310.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3283464cf0"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12477"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.12.003"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2014.12.006"}],"container-title":["Pediatric 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