{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T18:34:47Z","timestamp":1722191687998},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T00:00:00Z","timestamp":1453334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001828","name":"Erasmus Universiteit Rotterdam","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1056929"],"award-info":[{"award-number":["APP1056929"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC\u20102014\u2010CoG\u2010648916"],"award-info":[{"award-number":["ERC\u20102014\u2010CoG\u2010648916"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Exposure to low levels of vitamin D in fetal life might affect the developing immune system, and subsequently the risk of childhood eczema. We examined whether 25\u2010hydroxyvitamin D levels in mid\u2010gestation and at birth were associated with the risk of eczema until the age of 4 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a population\u2010based prospective cohort study of 3019 mothers and their children, maternal blood samples in mid\u2010gestation and umbilical cord blood samples at birth were used to determine 25\u2010hydroxyvitamin D levels (severely deficient &lt;25.0 nmol\/l, deficient 25.0\u201349.9 nmol\/l, sufficient 50.0\u201374.9 nmol\/l, optimal \u226575.0 nmol\/l). Eczema was prospectively assessed by annual questionnaires until the age of 4 years. Eczema patterns included never, early (age \u22641 year only), late (age &gt;1 year only), and persistent eczema (age \u2264 and &gt;1 year). Data were assessed using the generalized estimating equations and multinomial regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the optimal 25\u2010hydroxyvitamin D group, sufficient, deficient, and severely deficient groups of 25\u2010hydroxyvitamin D level in mid\u2010gestation were not associated with the risk of overall eczema (odds ratios [95% confidence interval]: 1.09 [0.82, 1.43], 1.04 [0.87, 1.25], and 0.94 [0.81, 1.10], p\u2010values for trend &gt;0.05), nor with eczema per year or eczema patterns in children up to the age of 4 years. Similarly, we observed no associations of 25\u2010hydroxyvitamin D groups at birth with any eczema outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that levels of 25\u2010hydroxyvitamin D in mid\u2010gestation and at birth are not associated with the risk of overall eczema, eczema per year, or eczema patterns among children until the age of 4 years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12530","type":"journal-article","created":{"date-parts":[[2015,12,19]],"date-time":"2015-12-19T06:23:49Z","timestamp":1450506229000},"page":"283-289","source":"Crossref","is-referenced-by-count":9,"title":["Associations of maternal and fetal 25\u2010hydroxyvitamin D levels with childhood eczema: The Generation R Study"],"prefix":"10.1111","volume":"27","author":[{"given":"Tatjana","family":"Gazibara","sequence":"first","affiliation":[{"name":"The Generation R Study Group Erasmus MC, University Medical Center Rotterdam Rotterdam The Netherlands"},{"name":"Department of Pediatrics, Division of Respiratory Medicine Erasmus MC, University Medical Center Rotterdam Rotterdam The Netherlands"},{"name":"Department of Epidemiology Erasmus MC, University Medical Center Rotterdam Rotterdam The Netherlands"},{"name":"Institute of Epidemiology, Faculty of Medicine University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels J.","family":"Elbert","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus MC, University Medical Center Rotterdam Rotterdam The Netherlands"},{"name":"Department of Dermatology Erasmus MC, University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herman T.","family":"den Dekker","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus MC, University Medical Center Rotterdam Rotterdam The Netherlands"},{"name":"Department of Pediatrics, Division of Respiratory Medicine Erasmus MC, University Medical Center Rotterdam Rotterdam The Netherlands"},{"name":"Department of Epidemiology Erasmus MC, University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan C.","family":"de Jongste","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Respiratory Medicine Erasmus MC, University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irwin","family":"Reiss","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology Erasmus MC, University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"McGrath","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland Brisbane Qld Australia"},{"name":"Queensland Centre for Mental Health Research, Park Centre for Mental Health Wacol Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darryl W.","family":"Eyles","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland Brisbane Qld Australia"},{"name":"Queensland Centre for Mental Health Research, Park Centre for Mental Health Wacol Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Burne","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland Brisbane Qld Australia"},{"name":"Queensland Centre for Mental Health Research, Park Centre for Mental Health Wacol Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Tiemeier","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus MC, University Medical Center Rotterdam Rotterdam The Netherlands"},{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus MC, University Medical Center Rotterdam Rotterdam The Netherlands"},{"name":"Department of Psychiatry Erasmus MC, University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent W. 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