{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:14:06Z","timestamp":1791274446481,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T00:00:00Z","timestamp":1454889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0601361"],"award-info":[{"award-number":["G0601361"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K002449\/1"],"award-info":[{"award-number":["MR\/K002449\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000362","name":"Asthma UK","doi-asserted-by":"publisher","award":["04\/014"],"award-info":[{"award-number":["04\/014"]}],"id":[{"id":"10.13039\/501100000362","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Skin prick tests (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>s) and allergen\u2010specific serum IgE (<jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>) measurements are the main diagnostic tools for confirming atopic sensitization. Results are usually reported as \u2018positive\u2019 or \u2018negative\u2019, using the same arbitrary cut\u2010offs (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>&gt;3 mm, <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>&gt;0.35 kU<jats:sub>A<\/jats:sub>\/l) across different ages and sexes. We investigated the influence of age and sex on the interpretation of allergy test in the context of childhood asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a population\u2010based birth cohort (n = 1051), we ascertained the information on asthma\/wheeze (validated questionnaires) and performed <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> measurement to inhalant allergens (dust mite, cat, dog) at follow\u2010ups between ages three and 11 years. We investigated the association between quantitative sensitization (sum of <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> mean wheal diameters [<jats:styled-content style=\"fixed-case\">MWD<\/jats:styled-content>] and <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> titres to the three allergens) and current wheeze and asthma across ages and sexes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed a significant association between the <jats:styled-content style=\"fixed-case\">SPT MWD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> titres and wheeze\/asthma at most ages and for both sexes. However, the strength of this association was age\u2010 and sex\u2010dependent. For <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>s, the strength of the association between <jats:styled-content style=\"fixed-case\">MWD<\/jats:styled-content> and asthma increased with increasing age; we observed the opposite pattern for <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> titre. For any given <jats:styled-content style=\"fixed-case\">SPT MWD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> titre, boys were significantly more likely to express clinical symptoms, particularly in early life; this difference between males and females diminished with age and was no longer significant by age 11 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Age and sex should be taken into account when interpreting the results of skin tests and <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> measurement, and age\u2010 and sex\u2010specific normative data are needed for these allergy tests.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12534","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T03:35:37Z","timestamp":1452742537000},"page":"313-319","source":"Crossref","is-referenced-by-count":41,"title":["Age, sex and the association between skin test responses and IgE titres with asthma"],"prefix":"10.1111","volume":"27","author":[{"given":"Hasan Raza","family":"Mohammad","sequence":"first","affiliation":[{"name":"Centre for Respiratory Medicine and Allergy Institute of Inflammation and Repair Manchester Academic Health Science Centre University of Manchester &amp; University Hospital of South Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Belgrave","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamilla","family":"Kopec Harding","sequence":"additional","affiliation":[{"name":"Centre for Respiratory Medicine and Allergy Institute of Inflammation and Repair Manchester Academic Health Science Centre University of Manchester &amp; University Hospital of South Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare S.","family":"Murray","sequence":"additional","affiliation":[{"name":"Centre for Respiratory Medicine and Allergy Institute of Inflammation and Repair Manchester Academic Health Science Centre University of Manchester &amp; University Hospital of South Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Simpson","sequence":"additional","affiliation":[{"name":"Centre for Respiratory Medicine and Allergy Institute of Inflammation and Repair Manchester Academic Health Science Centre University of Manchester &amp; University Hospital of South Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Custovic","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1989.tb02408.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90130-T"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.117464"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.09.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32835e82b6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.03.014"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2382"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.04.014"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00305.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.06.032"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01502.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12275"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70048-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1995.tb03255.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02412.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.09.026"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2013.5.3.162"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1992.tb02084.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(87)90292-2"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02728.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.13.s.15.3.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201309-1700OC"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043214"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001748"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(13)70277-7"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.03.041"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12139"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.03.027"},{"key":"e_1_2_7_30_1","article-title":"Distinguishing benign from pathologic T2 immunity in atopic children","author":"Holt PG","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12410"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.12534","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.12534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:36:24Z","timestamp":1695544584000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.12534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,8]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/pai.12534"],"URL":"https:\/\/doi.org\/10.1111\/pai.12534","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,8]]}}}