{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:04:59Z","timestamp":1788959099017,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T00:00:00Z","timestamp":1464307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005275","name":"Region Hovedstaden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Atopic dermatitis (AD<\/jats:styled-content>) is a chronic inflammatory skin condition with a multifactorial etiopathogenesis. Studies have suggested that several perinatal factors may influence the risk of AD<\/jats:styled-content> in early childhood. We investigated possible neonatal risk factors such as jaundice, blue light phototherapy, birthweight, gestational age at birth, and season of birth on the risk of developing AD<\/jats:styled-content> in the first 5\u00a0years of life.<\/jats:p><\/jats:sec>Materials & Methods<\/jats:title>Data were collected through Danish nationwide administrative registers. All newborn children between 1997 and 2007 (n\u00a0=\u00a0673,614) were included in the cohort. Incidence rate ratios (IRR<\/jats:styled-content>s) were estimated with 95% confidence intervals (95% CI<\/jats:styled-content>s) by multivariate Poisson regression analyses.<\/jats:p><\/jats:sec>Results<\/jats:title>We identified a total of 85,743 children with AD<\/jats:styled-content> in the first 5\u00a0years of life. The risk of AD<\/jats:styled-content> was slightly increased in children with neonatal jaundice (IRR<\/jats:styled-content> 1.13 [95% CI<\/jats:styled-content> 1.06\u20131.21]). Preterm birth was inversely associated with the risk of AD<\/jats:styled-content> (IRR<\/jats:styled-content> 0.74, [95% CI<\/jats:styled-content> 0.68\u20130.81]) as well as low birthweight (IRR<\/jats:styled-content> 0.68, [95% CI<\/jats:styled-content> 0.61\u20130.75]). Children born in fall and winter seasons had an increased risk of AD<\/jats:styled-content> compared to spring and summer. No association between neonatal blue light therapy and the risk of AD<\/jats:styled-content> was found.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Low birthweight and preterm birth were inversely associated with AD<\/jats:styled-content>, while neonatal jaundice and cold seasons of birth were associated with an increased risk of AD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12560","type":"journal-article","created":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T15:03:02Z","timestamp":1457362982000},"page":"368-374","source":"Crossref","is-referenced-by-count":41,"title":["Neonatal risk factors of atopic dermatitis in Denmark \u2013 Results from a nationwide register\u2010based study"],"prefix":"10.1111","volume":"27","author":[{"given":"Alexander","family":"Egeberg","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Allergology Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"},{"name":"Department of Cardiology Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki M. F.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"},{"name":"Department of Cardiology Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Gislason","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"},{"name":"The Danish Heart Foundation Copenhagen Denmark"},{"name":"The National Institute of Public Health University of Southern Denmark Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone","family":"Skov","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"},{"name":"The National Allergy Research Centre Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00149-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.19"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13301"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011040"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.12.013"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.005"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.07.060"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13497"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12170"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12581"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.89"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.194"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.3.1887"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt248"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01038.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"key":"e_1_2_6_19_1","first-page":"263","article-title":"The Danish National Hospital Register. 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