{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:14:02Z","timestamp":1791274442446,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T00:00:00Z","timestamp":1462492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prevalence, incidence and natural history of food hypersensitivity (<jats:styled-content style=\"fixed-case\">FHS<\/jats:styled-content>) and its trends in an unselected cohort of older children are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A birth cohort born on the Isle of Wight (<jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>) between 2001 and 2002 was followed up prospectively. Children were clinically examined and skin prick tested at set times and invited for food challenges when indicated. At 10 years of age, children were also invited for a blood test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 969 children were recruited at 12 weeks of pregnancy, and 92.9%, 88.5%, 91.6% and 85.3% were assessed at 1, 2, 3 and 10 years. Prevalence of sensitization to any allergen over 10 years was 186 of 969 (19.2%; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 16.84\u201321.8) and 108 of 969 (11.2%; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 9.31\u201313.29) children were sensitized to at least one predefined food allergen. Excluding wheat (due to cross\u2010reactivity with pollen), 40 of 969 (4.1%; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 3.19\u20135.32) children were sensitized to a predefined food allergen. Using food challenges and\/or a good clinical history, the cumulative incidence of food hypersensitivity (<jats:styled-content style=\"fixed-case\">FHS<\/jats:styled-content>) in the first decade of life was 64 of 947 (6.8%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 5.2\u20138.4), while the prevalence of <jats:styled-content style=\"fixed-case\">FHS<\/jats:styled-content> at 10 years was 30 of 827 (3.6%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.54\u20135.15). The vast majority, 25 of 827 (3.0%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.8\u20134.2), suffered from IgE\u2010mediated food allergy, while 5 of 827 (0.6%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.07\u20131.3) had non\u2010IgE\u2010mediated food allergy\/food intolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>By the age of 10 years, 6.8% of children suffered from <jats:styled-content style=\"fixed-case\">FHS<\/jats:styled-content> based on food challenges and a good clinical history. There was a large discrepancy between reported and diagnosed <jats:styled-content style=\"fixed-case\">FHS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12564","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T03:24:47Z","timestamp":1458617087000},"page":"452-458","source":"Crossref","is-referenced-by-count":34,"title":["Prevalence and cumulative incidence of food hyper\u2010sensitivity in the first 10 years of life"],"prefix":"10.1111","volume":"27","author":[{"given":"Carina","family":"Venter","sequence":"first","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St. Mary's Hospital Newport Isle of Wight UK"},{"name":"School of Health Sciences and Social Work University of Portsmouth Portsmouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veeresh","family":"Patil","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St. Mary's Hospital Newport Isle of Wight UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Grundy","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St. Mary's Hospital Newport Isle of Wight UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Glasbey","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St. Mary's Hospital Newport Isle of Wight UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Twiselton","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St. Mary's Hospital Newport Isle of Wight UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Hasan","family":"Arshad","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St. Mary's Hospital Newport Isle of Wight UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taraneh","family":"Dean","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St. Mary's Hospital Newport Isle of Wight UK"},{"name":"School of Health Sciences and Social Work University of Portsmouth Portsmouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.12.591"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12305"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2006.00428.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.05.047"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.12.1352"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01570.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.017"},{"key":"e_1_2_7_9_1","unstructured":"1998 G Smithers J Gregory WA Coward A Wright R Elsom R Wenlock British National Diet and Nutrition Survey of young people aged 4 to 18 years: feasibility study of the dietary assessment methodology. 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