{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:05:10Z","timestamp":1773446710092,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are some biomarkers for asthma diagnosis but they are often difficult in clinical use, particularly in pediatric cases. Periostin is an extracellular matrix protein, upregulated in response to <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 or <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013. Serum periostin is expected to be used as a non\u2010invasive biomarker for asthma diagnosis and management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010eight children with asthma (<jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>) and 27 children without asthma (patients with pectus excavatum, etc. as control group) aged 6\u201316 years were included. Bronchial asthma was diagnosed according to International Study of Asthma and Allergies in Childhood (<jats:styled-content style=\"fixed-case\">ISAAC<\/jats:styled-content>) questionnaire. Fractional exhaled nitric oxide (Fe<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>), lung function, blood eosinophil counts, total immunoglobulin E (IgE) levels, and serum periostin levels were assessed. Results were compared between <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> and controls. Asthma diagnostic accuracies were calculated using receiver operating characteristics (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) curve analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum periostin levels in the <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> group were significantly higher than those in the control group [medians (with interquartile ranges), 134.0 (116.3\u2013166.3) vs. 112.0 (97.0\u2013132.0) ng\/ml; p<jats:italic> =<\/jats:italic> 0.012]. The area under the <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>) for periostin, Fe<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>, and eosinophil counts were 0.70, 0.72, and 0.84, respectively. After the exclusion of controls with pectus excavatum, <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> for periostin, forced expiratory volume in 1 s (<jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content><jats:sub>1<\/jats:sub>), and maximum mid\u2010expiratory flow rate (<jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content>) were 0.75, 0.74, and 0.80, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum periostin levels were significantly higher in children with asthma. <jats:styled-content style=\"fixed-case\">ROC AUC<\/jats:styled-content> values for periostin were equivalent to conventional biomarkers, including Fe<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> levels and lung function testing, indicating the utility of serum periostin levels in diagnosing asthma in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12575","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T17:48:52Z","timestamp":1460310532000},"page":"521-526","source":"Crossref","is-referenced-by-count":62,"title":["Periostin as a biomarker for the diagnosis of pediatric asthma"],"prefix":"10.1111","volume":"27","author":[{"given":"Takashi","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Pediatrics Jikei University Daisan Hospital Tokyo Japan"},{"name":"Department of Pediatrics Sagamihara National Hospital Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Akashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jikei University Daisan Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jikei University Daisan 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