{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:33:19Z","timestamp":1761863599451},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T00:00:00Z","timestamp":1464307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSC 101\u20102314\u2010B\u2010400\u2010009\u2010MY2","MOST 103\u20102314\u2010B\u2010400\u2010004\u2010MY3"],"award-info":[{"award-number":["NSC 101\u20102314\u2010B\u2010400\u2010009\u2010MY2","MOST 103\u20102314\u2010B\u2010400\u2010004\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The longitudinal pattern of allergen\u2010specific IgE levels from the prenatal stage to early life has remained largely unexplored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One\u2010hundred and three mother\u2013infant pairs, which were part of an ongoing population\u2010based prospective birth cohort study of early childhood allergic diseases in Tainan, Taiwan, were included in this study. We examined the relationship of 20 allergen\u2010specific IgE levels with blood samples of mothers, cord blood, and infants at 12 months of age using Spearman rank correlation, Kenal \u03c4 and McNemar test, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Certain degree of IgE sensitization against most 20 examined specific allergens was observed in blood samples of mothers, cord blood, and infants at 12 months of age. When we further examined the association between allergy\u2010related risk factors and atopy in infants at the first year of life, we found positive association between colic pain and atopy in infants at 12 months of age [adjusted odds ratios (<jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content>) = 3.51; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 1.13\u201310.96; p = 0.03], and borderline significance between wheezing and atopy in infants at 12 months of age (<jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content> = 4.58; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.89\u201323.50; p = 0.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings from this study suggest that influence of maternal allergen\u2010specific IgE levels on infant immune response might occur at birth and then wane in infants at 12 months of age. Positive association of colic pain and wheezing with atopy in infants at 12 months of age provides supportive evidence for the \u2018Allergy March' theory of allergy development in an Asian birth cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12583","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T07:54:06Z","timestamp":1461052446000},"page":"620-626","source":"Crossref","is-referenced-by-count":3,"title":["Longitudinal pattern of multiplexed immunoglobulin E sensitization from prenatal stage to the first year of life"],"prefix":"10.1111","volume":"27","author":[{"given":"Jiu\u2010Yao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatrics College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Allergy and Clinical Immunology Research (ACIR) Center National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Ann","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Allergy and Clinical Immunology Research (ACIR) Center National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung\u2010I","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Allergy and Clinical Immunology Research (ACIR) Center National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan\u2010Lin","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Allergy and Clinical Immunology Research (ACIR) Center 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