{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:33:13Z","timestamp":1790742793169,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Late diagnosis of allergic bronchopulmonary aspergillosis (<jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content>) is associated with significant lung function decline and morbidity in cystic fibrosis (<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>). The association of <jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content> and domestic pet ownership in patients with <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> has not been elucidated yet. Our objective was to determine the association of <jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content> with pet ownership in patients with <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical and microbiological data from certified local patient registry were analyzed for 109 patients with <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> aged 1\u201364 years: 55 pet owner and 54 non\u2010pet owners. The primary outcome of the retrospective observational study was the occurrence of <jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content> in pet owners and non\u2010pet owners with <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>. The free statistical software R was utilized to investigate logistic regression models for association factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 109 patients included in the study, 61 (56%) were female. The mean age of the total group was 25.4 \u00b1 13.2 years. Adjusted analysis revealed that <jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5.0227, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.182\u201321.340, p = 0.029) was associated with pet ownership in patients with <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>. Furthermore, <jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content> in pet owners with <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> was associated with an increased number of exacerbations (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 6.446, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.057\u201339.328, p = 0.043). Other outcomes did not significantly differ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Owning a pet was associated with <jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>. Future prospective multicenter longitudinal studies are needed to investigate chronological causality between pet ownership, <jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content> development, and pulmonary exacerbations and to determine whether these estimates are generalizable for <jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content> susceptible patients beyond <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> (asthma, bronchiectasis).<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12590","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T16:25:02Z","timestamp":1462379102000},"page":"597-603","source":"Crossref","is-referenced-by-count":19,"title":["Allergic bronchopulmonary aspergillosis is associated with pet ownership in cystic fibrosis"],"prefix":"10.1111","volume":"27","author":[{"given":"Anja","family":"Thronicke","sequence":"first","affiliation":[{"name":"Department of Pediatric Pneumology and Immunology Cystic Fibrosis Center Berlin\/Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Heger","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Immunology Cystic Fibrosis Center Berlin\/Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Antweiler","sequence":"additional","affiliation":[{"name":"Reference Laboratory for Cryptococcosis, Scedosporiosis and Imported Systemic Mycoses FG16 Robert Koch Institute Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Krannich","sequence":"additional","affiliation":[{"name":"Biostatistics Unit Berlin Institute of Health Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin 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