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The aim of this study was to compare<jats:styled-content style=\"fixed-case\">sBT<\/jats:styled-content>levels in children with different severity of actual drug hypersensitivity reactions (<jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content>s) with those of age\u2010 and sex\u2010matched controls without any history of<jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients between 0 and 18 years of age with a history of immediate\u2010type<jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content>s manifested in 0\u20136 h after the culprit drug intake were included. Following<jats:styled-content style=\"fixed-case\">ENDA<\/jats:styled-content>(European Network for Drug Allergy) inquiries, patients were evaluated with skin and\/or provocation tests to define the actual drug\u2010hypersensitive patients. Serum<jats:styled-content style=\"fixed-case\">BT<\/jats:styled-content>levels were determined for both patients and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 345 children, 106 patients (30.7%) [(58.5% male), median age (interquartile range) 8.0 years (4.2\u201312.2)] were diagnosed as drug hypersensitive. Ninety\u2010eight controls were also included. The<jats:styled-content style=\"fixed-case\">sBT<\/jats:styled-content>levels of drug\u2010hypersensitive patients with and without anaphylaxis and the control group were similar [2.6 (2.0\u20133.6) \u03bcg\/l vs. 2.8 (1.6\u20134.3) \u03bcg\/l vs. 2.6 (1.8\u20133.6) \u03bcg\/l, respectively, (p &gt; 0.05)]. The<jats:styled-content style=\"fixed-case\">sBT<\/jats:styled-content>levels of the patients with sole cutaneous symptoms 2.8 (1.6\u20134.3) \u03bcg\/l, mild anaphylaxis 3.0 (1.9\u20104.9) \u03bcg\/l, and moderate\u2010to\u2010severe anaphylaxis 2.6 (2.0\u20133.6) \u03bcg\/l were also comparable (p &gt; 0.05). The onset of<jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content>s [those occurring in 1 h (n = 87) or in 1\u20136 h (n = 19) after the drug intake], positive results with skin tests with the culprit drug, or the classification of the patients according to different age groups [(0\u20132 years), (2\u20136 years), (6\u201312 years), (12\u201318 years)] did not correlate with<jats:styled-content style=\"fixed-case\">sBT<\/jats:styled-content>levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The<jats:styled-content style=\"fixed-case\">sBT<\/jats:styled-content>levels in children with actual drug hypersensitivity would not be a risk factor for severe systemic reactions on the contrary to children with allergic reactions to food or insect venom.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12604","type":"journal-article","created":{"date-parts":[[2016,6,11]],"date-time":"2016-06-11T14:16:44Z","timestamp":1465654604000},"page":"736-742","source":"Crossref","is-referenced-by-count":10,"title":["Basal serum tryptase is not a risk factor for immediate\u2010type drug hypersensitivity during childhood"],"prefix":"10.1111","volume":"27","author":[{"given":"Ozlem","family":"Cavkaytar","sequence":"first","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betul","family":"Karaatmaca","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru","family":"Arik Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University 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