{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:28:26Z","timestamp":1770812906035,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T00:00:00Z","timestamp":1468281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005674","name":"Funda\u00e7\u00e3o de Desenvolvimento da Pesquisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Local allergic rhinitis (<jats:styled-content style=\"fixed-case\">LAR<\/jats:styled-content>) is diagnosed by the positive response to nasal allergen provocation test (<jats:styled-content style=\"fixed-case\">NAPT<\/jats:styled-content>) to aeroallergen and\/or local synthesis of specific IgE (<jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>). This entity is found in half of the adults with non\u2010allergic rhinitis (<jats:styled-content style=\"fixed-case\">NAR<\/jats:styled-content>). In children, very few data of the prevalence and characteristics of <jats:styled-content style=\"fixed-case\">LAR<\/jats:styled-content> were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children 8\u201318\u00a0years with <jats:styled-content style=\"fixed-case\">NAR<\/jats:styled-content> were recruited. A <jats:styled-content style=\"fixed-case\">NAPT<\/jats:styled-content> with <jats:italic>Dermatophagoides pteronyssinus<\/jats:italic> extract (<jats:styled-content style=\"fixed-case\">NAPT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">Dp<\/jats:styled-content>) at 200, 600, and 2000\u00a0AU\/ml, respectively, at 15\u2010min interval was performed. The immediate response was assessed using the clinical symptom score, peak nasal inspiratory flow (<jats:styled-content style=\"fixed-case\">PNIF<\/jats:styled-content>), and acoustic rhinometry (<jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content>). The nasal tryptase and <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">Dp<\/jats:styled-content> were measured at baseline and 15\u00a0min and 1\u00a0h after a positive <jats:styled-content style=\"fixed-case\">NAPT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">Dp<\/jats:styled-content>. Two allergic rhinitis (<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>) patients were used as positive controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010four <jats:styled-content style=\"fixed-case\">NAR<\/jats:styled-content> children (61.1% boys) with the mean\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> age of 11.1\u00a0\u00b1\u00a02.1\u00a0years were enrolled. The median duration of disease was 6.3\u00a0years. The most frequent comorbidity was asthma (38.9%). Eighty\u2010seven percent of patients had mild persistent severity. <jats:styled-content style=\"fixed-case\">NAPT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">Dp<\/jats:styled-content> was positive in 2\/54 (3.7%) of <jats:styled-content style=\"fixed-case\">NAR<\/jats:styled-content> children who had increased symptom score and decreased minimal cross\u2010sectional area (<jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content>) on <jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> as well as <jats:styled-content style=\"fixed-case\">PNIF<\/jats:styled-content>. However, there was no change in the nasal tryptase and <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">Dp<\/jats:styled-content>. The control <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> patients had positive <jats:styled-content style=\"fixed-case\">NAPT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">Dp<\/jats:styled-content> and increased nasal tryptase at 15\u00a0min without the change of <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>\u2010Dp.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LAR<\/jats:styled-content> is an uncommon condition in children. Further investigation in a large population of children with <jats:styled-content style=\"fixed-case\">NAR<\/jats:styled-content> is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12606","type":"journal-article","created":{"date-parts":[[2016,6,11]],"date-time":"2016-06-11T14:22:41Z","timestamp":1465654961000},"page":"574-579","source":"Crossref","is-referenced-by-count":31,"title":["The proportion of local allergic rhinitis to <i>Dermatophagoides pteronyssinus<\/i> in children"],"prefix":"10.1111","volume":"27","author":[{"given":"Pichittra","family":"Buntarickpornpan","sequence":"first","affiliation":[{"name":"Division of Allergy and Immunology Department of Pediatrics Faculty of Medicines Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jittima","family":"Veskitkul","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology Department of Pediatrics Faculty of Medicines Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Punchama","family":"Pacharn","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology Department of Pediatrics Faculty of Medicines Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nualanong","family":"Visitsunthorn","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology Department of Pediatrics Faculty of Medicines Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pakit","family":"Vichyanond","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology Department of Pediatrics Faculty of Medicines Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pongsakorn","family":"Tantilipikorn","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Allergy Department of Otolaryngology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orathai","family":"Jirapongsananuruk","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology Department of Pediatrics Faculty of Medicines Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.138"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.115562"},{"key":"e_1_2_7_4_1","first-page":"1","article-title":"International consensus report on the diagnosis and management of rhinitis","volume":"49","author":"International Rhinitis Management Working Group","year":"1994","journal-title":"Allergy"},{"key":"e_1_2_7_5_1","first-page":"8","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)","volume":"86","author":"Bousquet J","year":"2008","journal-title":"Allergy"},{"key":"e_1_2_7_6_1","first-page":"270","article-title":"Clinical characteristics of children with non\u2010allergic rhinitis vs with allergic rhinitis","volume":"28","author":"Vichyanond P","year":"2010","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01355.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.02.018"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3839"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)90056-2"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.01.006"},{"key":"e_1_2_7_12_1","first-page":"86","article-title":"Seasonal non\u2010allergic rhinitis (SNAR)\u2013a new disease entity? 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