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Children were followed up prospectively, skin prick tested (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>) to peanut allergens at 1, 2, 3 and 10\u00a0years and food challenges performed. The Isle of Wight (<jats:styled-content style=\"fixed-case\">IOW<\/jats:styled-content>) birth cohort was established in 1989 (n\u00a0=\u00a01456). <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>s were performed at 1, 2, 4 and 10\u00a0years. Peanut allergy was based on positive <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> and a good clinical history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the <jats:styled-content style=\"fixed-case\">FAIR<\/jats:styled-content> cohort, the prevalence of sensitization to peanut was 0.4%, 2.0%, 2.0% and 2.4% at 1, 2, 3 and 10\u00a0years, respectively. At 10\u00a0years of age, 12 of 828 (1.5%) children were diagnosed with peanut allergy. One child (8%) outgrew her peanut allergy between 3 and 10\u00a0years and two children (15%) presented with new onset peanut allergy. Over the first 10\u00a0years of life, 13 of 934 (1.4%) children were diagnosed with peanut allergy. In the <jats:styled-content style=\"fixed-case\">IOW<\/jats:styled-content> cohort, 6 of 1034 (0.58%) were diagnosed with peanut allergy at 10\u00a0years. We found no significant differences between the <jats:styled-content style=\"fixed-case\">FAIR<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">IOW<\/jats:styled-content> birth cohort for any of the time points studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Peanut allergy appears to be stable over the first 10\u00a0years of life in our cohorts. There was no significant difference in peanut sensitization or clinical peanut allergy between 1989 and 2001.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12616","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T15:46:44Z","timestamp":1468943204000},"page":"804-811","source":"Crossref","is-referenced-by-count":55,"title":["The prevalence, natural history and time trends of peanut allergy over the first 10\u00a0years of life in two cohorts born in the same geographical location 12\u00a0years apart"],"prefix":"10.1111","volume":"27","author":[{"given":"Carina","family":"Venter","sequence":"first","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St. Mary's Hospital Newport UK"},{"name":"School of Health Sciences and Social Work University of Portsmouth Portsmouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Maslin","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St. Mary's Hospital Newport UK"},{"name":"School of Health Sciences and Social Work University of Portsmouth Portsmouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veeresh","family":"Patil","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St. Mary's Hospital Newport UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Kurukulaaratchy","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St. Mary's Hospital Newport UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Grundy","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St. Mary's Hospital Newport UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Glasbey","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St. Mary's Hospital Newport UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Twiselton","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St. Mary's Hospital Newport UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taraneh","family":"Dean","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St. Mary's Hospital Newport UK"},{"name":"School of Health Sciences and Social Work University of Portsmouth Portsmouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Hasan","family":"Arshad","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St. Mary's Hospital Newport UK"},{"name":"Clinical &amp; Experimental Sciences Faculty of Medicine University of Southampton Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.01.017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12423"},{"issue":"6","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaci.2010.10.008","article-title":"Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID\u2010sponsored expert panel","volume":"126","author":"Boyce JA","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70224-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.03.029"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-007-0018-y"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.09.026"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.01.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.05.047"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02176.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01570.x"},{"key":"e_1_2_8_13_1","unstructured":"Committee on Toxicity of Chemicals in Food Consumer Products and the Environment. 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